A human osteogenic sarcoma cell culture is useful in the immunofluorescence serological test for detecting human cytomegalovirus antibody. These sarcoma cells are chronically infected with human cytomegalovirus and provide a constant number of immunofluorescence-positive cells.

The effectiveness of the antiviral agent ganciclovir (9-[1,3-dihydroxy-2-propoxymethyl]guanine) against guinea pig cytomegalovirus was tested in vitro in guinea pig embryonic fibroblasts and in vivo in an experimental guinea pig cytomegalovirus labyrinthitis model. In vitro, ganciclovir completely prevented guinea pig cytomegalovirus infection of guinea pig embryonic fibroblasts at concentratio...

We report a 37 year old Chinese woman with systemic lupus erythematosus complicated by concomitant cytomegalovirus pneumonia and alveolar haemorrhage. The cytomegalovirus pneumonia may have been causally related to the alveolar haemorrhage.

Cytomegalovirus colitis is common in immunocompromised patients, but rare in immunocompetent patients. The present study not only represents the colonoscopy and pathological findings, but also applies the method of diagnosing and treating cytomegalovirus colitis in immunocompetent patients.

A fluorescein isothiocyanate-labeled monoclonal cytomegalovirus antibody reagent incorporating Evans blue (Syva/Genetic Systems, Palo Alto, Calif.) was compared to a fluorescein isothiocyanate-labeled polyclonal antibody (Dynatech Diagnostics, Inc., South Windham, Maine) for identification of cytomegalovirus in tissue culture. A total of 191 cultures, 86 positive and 105 negative for cytomegalo...

OBJECTIVE To determine the prevalence of congenital cytomegalovirus infection in newborn infants admitted to an intensive care unit in a public hospital in Porto Alegre. METHODS A cross-sectional study of 261 newborn infants born at a public hospital in the city of Porto Alegre in 2003 and admitted to the intensive care ward. Urine samples were collected within 7 days of birth and a polymeras...

BACKGROUND AND OBJECTIVE Cases presenting with intestinal perforation and obstruction constitute a substantial work load on our surgical service. Etiologies vary in underdeveloped and developed countries. Histopathological examination of resected intestine is expected to provide the definite evidence of the underlying etiology- guiding a better health care planning for preventive measures. Our ...

Polyomavirus-related infections are ubiqutious in immunocompromised individuals, and some cases intractable fatal. Due to a lack of approved drugs treat polyomavirus infections, cidofovir, phosphonate nucleotide analog cytomegalovirus has been repurposed as an antipolyomavirus agent.

BACKGROUND The hypothetical responsibility of sperm donation in cytomegalovirus (CMV) transmission to recipients and precautions to prevent this transmission are widely discussed. The aim of this French CECOS Federation study was to evaluate both the reality and the importance of the CMV risk due to donor sperm and the relevance of measures used to screen it. METHODS We conducted a prospectiv...

The epidemiology and pathogenesis of CMV infections among pregnant women have been intensely studied over the last three decades. This paper highlights recent developments that make either universal or limited serologic screening for CMV during pregnancy potentially attractive. The developments include an understanding of the pathogenesis of CMV infections, a knowledge of high-risk women, the a...