We used enzyme digestion to isolate cells from aortas of Rhesus monkeys (Macaca mulatto) fed on control or atherogenic diets for 19-21 months and subjected them to Metrizamide density gradient centrifugation. A majority of the cells from both control and experimental animals equilibrated in the density range of 1.08-1.12, but an additional population of cells (about 10% of the total) equilibrat...

Peripherally active anorectic agents represent a new approach to the pharmacological management of obesity. Two inhibitors of carbohydrate absorption: an alpha-glucosidase inhibitor, acarbose (Bay g 5421) and a alpha-amylase inhibitor, Ro 12-2272, were compared with two novel inhibitors of lipid metabolism: an inhibitor of human pancreatic lipase (Ro 20-0083) and of hepatic fatty acid synthesis...

Abstract Cellular metabolism provides fundamental components for chromatin dynamics and epigenetics. However, metabolic features, their impact on epigenetic remodeling during mammalian pre-implantation development, remain poorly understood. In this study, we established the landscape of mouse embryos from zygote to blastocyst, quantified absolute carbohydrate metabolites. We found that amino ac...