BACKGROUND There are currently many approved agents for the treatment of metastatic melanoma (MM), the most aggressive form of skin cancer. Treatments may include systemic therapies such as ipilimumab, dacarbazine, temozolomide, high-dose interleukin 2, interferon α, dacarbazine- or temozolomide-based combination chemotherapy/biochemotherapy, paclitaxel, paclitaxel/cisplatin, and paclitaxel/car...

Although eosinophilia is a recognised associated feature of Hodgkin’s Lymphoma, hypereosinophilia seldom the presenting in patient. Here, authors report an unusual case 21-year-old male patient who presented to General Medicine outpatient department hospital with history multiple episodes left-sided pleural effusion addition mediastinal and cervical lymphadenopathy. Baseline investigations reve...

Roughly speaking, the semialgebraic cell decomposition theorem for p-adic numbers describes piecewise the p-adic valuation of p-adic polyno-mials (and more generally of semialgebraic p-adic functions), the pieces being geometrically simple sets, called cells. In this paper we prove a similar cell decomposition theorem to describe piecewise the valuation of analytic functions (and more generally...

Low J rotational transitions of 4HeH1, 4HeD1, 3HeH1, and 3HeD1 were observed in the 2–5 THz region with a high-precision far-infrared spectrometer. Dunham coefficients Ykl and isotopically independent parameters Ukl , D He kl , and D H kl were determined. In particular, D parameters with k ­ 0 and l ­ 1, 2 were determined with unprecedented accuracy, and provide important information for breakd...

The role of phonology in word recognition was investigated in 6 lexical-decision experiments involving homophones (e.g., MAID-MADE). The authors' goal was to determine whether homophone effects arise in the lexical-decision task and, if so, in what situations they arise, with a specific focus on the question of whether the presence of pseudohomophone foils (e.g., BRANE) causes homophone effects...

A novel 2,4,5-triaryl-substituted imidazole (IZCM-1) has been found to display distinct and specific fluorescence enhancement upon binding to parallel G-quadruplexes. Such a sensitive and topology-specific probe is able to light up without affecting the topology or thermal stability of the G-quadruplex sample. Thus, these advantages distinguish IZCM-1 from other G-quadruplex probes.