Type 2 diabetes (T2D) and ageing have well documented effects on every organ in the body. In T2D the autonomic nervous system is impaired due to damage to neurons, sensory receptors, synapses and the blood vessels. This paper will concentrate on how autonomic impairment alters normal daily activities. Impairments include the response of the blood vessels to heat, sweating, heat transfer, whole ...

abstract   background: sacroiliac joint (sij) dysfunction is a widely known but poorly defined   cause of low back pain. to our knowledge, few published studies have been   conducted to evaluate systematically the prevalence and significance of concomitant   sacroiliac joint dysfunction in patients with herniated lumbar discs. as concomitant   sij dysfunction in low back pain patients is likely...

abstract   background: sacroiliac joint (sij) dysfunction is a widely known but poorly defined cause of low back pain. to our knowledge, few published studies have been conducted to evaluate systematically the prevalence and significance of concomitant sacroiliac joint dysfunction in patients with herniated lumbar discs. as concomitant sij dysfunction in low back pain patients is likely to resp...

INTRODUCTION Constipation is a common problem in intensive care units. We assessed the efficacy and safety of laxative therapy aiming to promote daily defecation in reducing organ dysfunction in mechanically ventilated patients. METHODS We conducted a prospective, randomized, controlled, nonblinded phase II clinical trial at two general intensive care units. Patients expected to remain ventil...

Although increased levels of circulating interleukin (IL)-18 have been demonstrated in patients with cardiovascular diseases, the functional consequences of chronically increased circulating IL-18 with respect to myocardial function have not been defined. Thus we aimed to examine the effects of chronic IL-18 exposure on left ventricular (LV) function in healthy mice. Moreover, to clarify whethe...

BACKGROUND Ocular pathology lessens light's efficacy to maintain optimal circadian entrainment. We examined whether ophthalmic dysfunction explains unique variance in melatonin excretion of older adults over and above the variance explained by daily illumination, medical, and sociodemographic factors. We also examined whether ophthalmic dysfunction influences relationships between ambient illum...

Objective: the objective of the study was to evaluate the impact of dizziness on the performance of daily practices in temporomandibular disorders (TMD) patients using the Activities-specific Balance Confidence Scale (ABC) and Dizziness Handicap Inventory (DHI) questionnaires. Methods: we evaluated 20 women with a mean age of 52.3 years from February 2014 to July 2015. The following were carrie...

BACKGROUND It is well established that acute ischemic preconditioning (IPC) protects against ischemia-reperfusion (IR) injury; however, the effectiveness of repeated IPC exposure has not been extensively investigated. We aimed to determine whether daily IPC episodes provide continued protection from IR injury in a human forearm model, and the role of cyclooxygenase-2 in these responses. METHO...

Aim Delirium is commonly encountered in daily clinical practice. To identify predictors influencing outcomes, we retrospectively examined the characteristics of inpatients with delirium who required psychiatric medication during hospitalization. Methods We extracted all new inpatients (n=523) consulted for psychiatric symptoms at Fukushima Medical University Hospital between October 2011 and ...

OBJECTIVE We aimed to investigate the prevalence and independent predictors of prolonged gastrointestinal dysfunction in critically ill patients admitted to the intensive care unit. METHODS Retrospective and observational cohort study performed in a mixed 24 beds intensive care unit in a tertiary center. Patients admitted in the intensive care unit between August 2003 and January 2004, who ha...