Address correspondence to: 12 13 Paul W. Hruz, 14 Washington University School of Medicine, 15 660 S. Euclid Ave., Campus Box 8208, 16 St. Louis, MO 63110. 17 Tel.: 314-286-2797; Fax: 314-286-2892; E-mail: [email protected] . 18 19 Christian Callebaut, 20 Gilead Sciences, 21 333 Lakeside Dr., 22 Foster City, CA 94404. 23 Tel: 650-522-6362 Fax: 650-522-5143; Email: christian.callebaut@gilead...

The IGF system has been implicated in cardiovascular disease (CVD) development. The prospective association of serum IGF-I and IGF-binding protein-1 (IGFBP-1) with all cause, ischemic heart disease (IHD), and non-IHD CVD mortality was examined in 633 men and 552 nonestrogen-using postmenopausal women, aged 51-98 yr (mean, 74 yr) in 1988-1992, who were followed through July 2001 (96% follow-up)....

whether for the delay in payment of debt resulting from civil liability can be demand late payment damages? in answering this question, answer of some of lawyers is positive. they believed that late payment damages is accrued to debt resulting from civil liability. because, these creditors are more deserving of protection. also, the word of debt in article 522 of code civil procedure is absolut...

There have been amazing advances in embryology, teratology, reproductive biology, genetics, andepidemiology in the past 50 years that have provided scientists and clinicians with a better perspective on the causes of congenital malformations. We still cannot provide the families of children with malformations a definitive 434SURAKSHA AGRAWAL Author’s Address: Prof. Suraksha Agrawal, Dep...

This study reports that a selective COX-2 inhibitor JTE-522inhibits both in vitro and in vivo growth of human lung cancer cells as a single agent. Furthermore, the adjunct use of JTE-522 is shown to significantly enhance treatment efficacy of conventional anticancer drugs not only in vitro but also in vivo without causing any noticeable side effects. Indeed, IC(50)s of various anticancer agents...

An optical parametric oscillator (OPO) based on magnesium-oxide-doped periodically poled lithium niobate (MgO:PPLN) is demonstrated to deliver visible femtosecond pulses, which were created through the intra-cavity nonlinear interactions within the PPLN itself. The signal from the OPO produces femtosecond pulses in the near-infrared region tunable from 1050 to 1600 nm. Visible femtosecond pulse...

BACKGROUND A sizable majority of adult Internet users report looking for health information online. Social networking sites (SNS) like Facebook represent a common place to seek information, but very little is known about the representation and use of health content on SNS. OBJECTIVE Our goal in this study was to understand the role of SNS in health information seeking. More specifically, we a...

We assessed the magnitude of the genetic component in the variation of circulating levels of insulin-like growth factors I and II (IGF-I and IGF-II), and their binding proteins IGFBP-1 and IGFBP-3 by measuring their serum concentrations in 32 monozygotic and 47 dizygotic adult twin pairs of the same sex. The intrapair correlation for the IGF-I levels was r = 0.41 (P < 0.009) for monozygotic twi...

We recently reported the outcomes of 421 consecutive patients with immunoglobulin light chain (AL) amyloidosis treated with highdose melphalan and autologous stem cell transplantation (HDM/ SCT)1 from July 1994 through December 2008. Median survival was 6.3 years and the complete response rate for evaluable patients was 43%. Treatment-related mortality (TRM) was 11.4%. In other studies of HDM/S...