We aimed to evaluate the potential of growing rats as a model of osteoporosis induced by short term hypercholesterolemia. Twelve growing female Sprague-Dawley rats were randomly allocated into two groups. Control rats received standard diet while rats in group 2 were fed with diet contained 20% sunflower oil, 2% cholesterol and 0.5% cholic acid for 2 weeks and then a diet contained 10% sunflowe...

Background Alzheimer’s is most common neurodegenerative disorder characterized by memory loss due to accumulation of amyloid- β fibrils. There are different pathologies that count for AD like neuro-inflammation. This study highlights the role oxidative stress and inflammation in progression whereas Perillyl alcohol (POH) shows ant & anti-inflammatory properties. Method 54 Sprague Dawley ICV-STZ...

Background: Medial prefrontal cortex (mPFC) is considered to be involved in human cognition mPFCin terms of learning and memory. Hypoxia one the crucial factors causing secondary damage incerebral hemorrhage traumatic brain injury. However, underlying mechanisms possibletherapeutic approach prevent neuronal has not been attempted yet. Therefore, present studyaimed investigate role Tualang honey...

The effect of partial hepatectomy on aflatoxin B! (AFB,) carcinogenesis in rat liver has been examined in Fischer and Sprague-Dawley rats. Partial hepatectomy performed before or after the administration of AFB, had no effect on the development of hepatocarcinoma, compared to either sham hepatectomy or no operation. When AFB, administration was begun 6 hr after either hepatectomy or sham operat...

The Lewis (LEW) and Fischer 344 (F344) inbred rat strains react differentially to acute morphine administration for a variety of behavioral and neurochemical measures. Investigations into effects of chronic morphine are less common, and investigations assessing dependence have been limited to those utilizing antagonist-precipitated withdrawal. The present experiment extended these assessments b...

To investigate the effect of sustained-release growth factor biomaterials on tendon healing in rats. A total 45 healthy adult Sprague-Dawley rats were randomly divided into 3 groups viz. blank group, vascular endothelial group and basic fibroblast with 15 each group. The injected 0.2 ml (100 ng) respectively. They again 7th d, 14th d 21st after operation. At 2, 4 6 w operation, selected for exp...

The beneficial immunomodulation effects of a biological response modifier glucan (BRMG) produced by two strains Aureobasidium pullulans, AFO-202 and N-163, have already been reported. Herein, we compared their efficacy on immune-inflammatory parameters in Sprague Dawley (SD) rats. This study was performed four groups healthy SD rats, n=6 each group: Group 1, euthanised Day 0 for baseline values...

Objective: In this study, we aimed to analyze the effects and underlying mechanisms of LPM570065 on behavioral phenotypes in rats with generalized anxiety disorder (GAD).Methods: The chronic unpredictable mild stress (CUMS) were used observe results LPM570065. Total 72 male Sprague Dawley divided into control, vehicle (0.5% CMC-Na), (32 mg/kg) diazepam (3 groups, 12 each group. Anxiety-like beh...

Purpose: To investigate the function of eriocalyxin B (EriB) in membranous nephropathy (MN) a rat model and related mechanisms.
 Methods: Cationic C-BSA was injected into Sprague-Dawley (SD) rats to generate MN. The MN were treated with different concentrations EriB (2.5, 5, 10 mg/kg). After treatment, their kidneys excised, sectioned, hematoxylin eosin (H&E) stained determine renal in...

Post-traumatic stress disorder (PTSD) is prevalent in women; however, preclinical research on PTSD has predominantly been conducted male animals. Using a predator scent (PSS) rodent model of PTSD, we sought to determine if stress-susceptible female rats show altered monoamine concentrations brain regions associated with PTSD: the medial prefrontal cortex (mPFC), nucleus accumbens (NAc), and dor...