Dosage compensation in Drosophila melanogaster involves the assembly of the MSL-2-containing dosage compensation complex (DCC) on the single X chromosome of male flies. Translational repression of msl-2 mRNA blocks this process in females. Previous work indicated that the ubiquitous protein Upstream of N-ras (UNR) is a necessary co-factor for msl-2 repression in vitro. Here, we explore the func...

Based on simulated reflectance, deep convective clouds (DCC) can be used as an invariant target to monitor the radiometric response degradation of the FY-3A/MERSI (Medium Resolution Spectral Imager) reflective solar bands (RSBs). The long-term response of the MERSI RSBs can easily be predicted using a quadratic fit of the monthly DCC mean reflectance, except for bands 6 and 7, which suffer from...

Tse and Zdancewic have formalized the notion of noninterference for Abadi et al.’s DCC in terms of logical relations and given a proof of noninterference by reduction to parametricity of System F. Unfortunately, their proof contains errors in a key lemma that their translation from DCC to System F preserves the logical relations defined for both calculi. In fact, we have found a counterexample ...

Paranodal axoglial junctions are critical for maintaining the segregation of axonal domains along myelinated axons; however, the proteins required to organize and maintain this structure are not fully understood. Netrin-1 and its receptor Deleted in Colorectal Cancer (DCC) are proteins enriched at paranodes that are expressed by neurons and oligodendrocytes. To identify the specific function of...

We investigated the roles of netrin-1 and slit-2 in regulation and navigation of dopamine (DA) axon growth using an explant culture preparation of embryonic ventral midbrain (embryonic day 14) and a co-culture system. We found that netrin-1 protein significantly enhanced DA axonal outgrowth and promoted DA axonal outgrowth in a co-culture system of netrin-1 expressing cells. Such effects were m...

The deleted in colorectal cancer (DCC) gene encodes a neural cell adhesion family molecule that was originally identified as a candidate tumor suppressor target of 18q allelic loss in colorectal cancer. However, the importance of the DCC protein has been most clearly demonstrated in neural development. Mutational and subsequent biochemical studies in C. elegans, Drosophila and vertebrates have ...

The cells expressing the T674I point mutant of FIP1-like-1-platelet-derived growth factor receptor alpha (FIP1L1-PDGFRα) in hypereosinophilics syndrome (HES) are resistant to imatinib and some second-generation tyrosine kinase inhibitors (TKIs). There is a desperate need to develop therapy to combat this acquired drug resistance. DCC-2036 has been synthesized as a third-generation TKI to combat...

The growth and guidance of many axons in the developing nervous system require Netrin-mediated activation of Deleted in Colorectal Cancer (DCC) and other still unknown signaling cues. Commissural axon guidance defects are more severe in DCC mutant mice than Netrin-1 mutant mice, suggesting additional DCC activating signals besides Netrin-1 are involved in proper axon growth. Here we report that...

Relativistic nuclear collisions can produce matter in which chiral symmetry is restored. One possible consequence of this restoration is the formation of disoriented chiral condensates (DCC) – transient regions in which the average chiral order parameter differs from its value in the surrounding vacuum. Previous efforts to describe DCC signals have focused on pion production. In Ref. [1], Gavin...

• Typically it takes place in a health centre or clinic, at the beginning of the day, when the patients have arrived. Health talks are also commonly given to the patients in a hospital ward. • The subject matter is decided upon by the health care staff, often in advance – they may have a programme worked out for the month. Often the subject matter is related to the medical programme for the day...