Clathrin-mediated endocytosis dynamically regulates cell membrane abundance of CFTR and plays an essential role in CFTR-dependent Cl(-) conductance in fluid-transporting epithelia. It requires two closely related, but distinct processes: assembly of the clathrin coat and recruitment of cargo proteins for endocytosis. The assembly polypeptide-2 complex (AP-2) is the prototypical endocytic adapto...

let $mathfrak{a}$ be an algebra. a linear mapping $delta:mathfrak{a}tomathfrak{a}$ is called a textit{derivation} if $delta(ab)=delta(a)b+adelta(b)$ for each $a,binmathfrak{a}$. given two derivations $delta$ and $delta'$ on a $c^*$-algebra $mathfrak a$, we prove that there exists a derivation $delta$ on $mathfrak a$ such that $deltadelta'=delta^2$ if and only if either $delta'=0$...

poverty is the most serious threat to natural resources and the environment and most of the poor are rural-based who engage in various agricultural activities. land is a critical asset for the rural poor and lacking means to appropriately intensify agriculture which compels the poor to either overuse or misuse this natural resource base to meet basic needs. this study presents empirical relatio...

as special depositional environments which are adjacent to the seas, deltas have provided a field for human habitat establishment. geomorphic features of deltas are in constant transformation due to their dynamic features. constructing dams on rivers can intensify these changes and cause either negative or positive consequences. minab delta in hormozgan province of iran is a round or crescent-s...

the aim of this paper is to introduce and study a new concept ofstrong double $(a)_ {delta}$-convergent sequence offuzzy numbers with respect to an orlicz function and also someproperties of the resulting sequence spaces of fuzzy   numbers areexamined. in addition, we define the double$(a,delta)$-statistical convergence of fuzzy  numbers andestablish some connections between the spaces of stron...

The harmonic index of a graph $G$, denoted by $H(G)$, is defined asthe sum of weights $2/[d(u)+d(v)]$ over all edges $uv$ of $G$, where$d(u)$ denotes the degree of a vertex $u$. Hu and Zhou [Y. Hu and X. Zhou, WSEAS Trans. Math. {bf 12} (2013) 716--726] proved that for any bicyclic graph $G$ of order $ngeq 4$, $H(G)le frac{n}{2}-frac{1}{15}$ and characterize all extremal bicyclic graphs.In this...

Cystic Fibrosis (CF) is the most commonly inherited potentially lethal disease amongst Caucasian children and young adults. In Europe, approximately 35,000 children and adults are affected by CF. The prevalence in the US and in Canada is approximately 30,000 and 3,000, respectively. CF is an autosomal recessive disorder and is caused by mutations in the Cystic Fibrosis Transmembrane Conductance...