[PDF] [Full Text] , April 1, 2007; 97 (4): 2577-2578. J Neurophysiol A. G. Dimitrov Dendrite-Dependent Mechanisms" Interspike Intervals as Indicators of Stimulus Intensity" and "Interval Coding. II. Pings the Body Electric (and Means It Too). Focus on "Interval Coding. I. Burst [PDF] [Full Text] [Abstract] , April 1, 2007; 97 (4): 2744-2757. J Neurophysiol B. Doiron, A.-M. M. Oswald and L. M...

A reversible plating/stripping of a dendrite-free metallic-sodium anode with a reduced anode/ceramic interfacial resistance is created by a thin interfacial interlayer formed in situ or by the introduction of a dry polymer film. Wetting of the sodium on the interfacial interlayer suppresses dendrite formation and growth at different discharge/charge C-rates. All-solid-state batteries were obtai...

We present a stochastic model of NMDA ( N-methyl d-aspartate) receptor transport along a dendrite prior to synapse formation. Receptors undergo periods of intracellular kinesin motor-driven transport along microtubules interspersed with periods of cycling to the cell surface through exocytosis or endocytsosis. The stochastic dynamics is reduced to a spatially discrete hopping model that determi...

We have developed an analog very-large-scale integrated (aVLSI) electronic circuit that emulates a compartmental model of a neuronal dendrite. The horizontal conductances of the compartmental model are implemented as a switched capacitor network. The transmembrane conductances are implemented as transconductance amplifiers. The electrotonic properties of our silicon cable are qualitatively simi...

The mitotic kinesin-like protein 1 (MKLP1) is specifically localized to the dendrite of the developed neuron, but its targeting mechanism is still unclear. In this study, the role of distinct domains of MKLP1 in dendritic targeting was investigated by producing a series of enhanced green fluorescent protein (eGFP)-tagged MKLP1 and its variant mutations, and studying the distribution of these mo...

Dendritic spines are small protrusions on a neuronal dendrite that are the main locus of excitatory synaptic connections. Although their geometry is variable over time and along the dendrite, they typically consist of a relatively large head connected to the dendritic shaft by a narrow cylindrical neck. The surface of the head is connected smoothly by a funnel or non-smoothly to the narrow neck...

The ubiquitin ligase anaphase-promoting complex (APC) recruits the coactivator Cdc20 to drive mitosis in cycling cells. However, the nonmitotic functions of Cdc20-APC have remained unexplored. We report that Cdc20-APC plays an essential role in dendrite morphogenesis in postmitotic neurons. Knockdown of Cdc20 in cerebellar slices and in postnatal rats in vivo profoundly impairs the formation of...

Spike timing-dependent synaptic plasticity (STDP) serves as a key cellular correlate of associative learning, which is facilitated by elevated attentional and emotional states involving activation of adrenergic signaling. At cellular levels, adrenergic signaling increases dendrite excitability, but the underlying mechanisms remain elusive. Here we show that activation of β2-adrenoceptors promot...

Phase-field simulations are used to examine tip velocity and shape selection in free dendritic growth of a pure substance into an undercooled melt in the presence of a density change between the solid and liquid. The dendrite is assumed to grow two-dimensionally inside a Hele-Shaw cell. The phase-field model is coupled with a previously developed two-phase diffuse interface model to simulate th...