Kang Shen is an investigator in the Howard Hughes Medical Institute and an associate professor in the Department of Biology at Stanford University. His laboratory studies synapse formation in C. elegans and mammals with a focus on synaptic target recognition, presynaptic assembly, and axonal transport. Introduction The wiring of the nervous system is arguably the most challenging question in de...

Dendrite and synapse development are critical for establishing appropriate neuronal circuits, and disrupted timing of these events can alter neural connectivity. Using microarrays, we have identified a nuclear factor I (NFI)-regulated temporal switch program linked to dendrite formation in developing mouse cerebellar granule neurons (CGNs). NFI function was required for upregulation of many syn...

Residual stress and lattice defects in commercial zinc anodes are essential factors for dendrite formation during deposition as they lead to a heterogeneous limit the epitaxial growth of zinc. In their Research Article (e202218612), Haiyan Wang et al. propose an annealing strategy defect repair residual relief. As result, reconstructed anode achieved highly growth. Heritage Science Fluoridation...

Dendrite development of newborn granule cells (GCs) in the dentate gyrus of adult hippocampus is critical for their incorporation into existing hippocampal circuits, but the cellular mechanisms regulating their dendrite development remains largely unclear. In this study, we examined the function of brain-derived neurotrophic factor (BDNF), which is expressed in adult-born GCs, in regulating the...

Aqueous zinc-ion batteries (AZIBs) have become attractive energy storage devices, owing to their high density, low cost, and environmental friendliness. However, the stability of zinc-metal anode has been retarded by dendrites side reactions during cycling process, limiting its practical application in secondary batteries. In this work, porous titanium nitride (TiN) nanosheets with a surface ar...

Evidence has been obtained that the microtubules of the insect sensory dendrite may originate from the nine pairs of peripheral fibrils in the ciliary portion of the dendrite and retain direct continuity with them. The peripheral fibrils separate and each of the single fibrils resulting appears to divide one or more times. The number of microtubules within the dendrite distal to the ciliary reg...

In neuron-biology, 3D neuron dendrite reconstruction followed by spine identification is indispensable for the study of neuronal functions and biophysical properties. In this paper, we propose an automatic dendrite reconstruction method to with a surface representation of the neuron on the basis of a novel level set approach. Our novel level set approach can effectively tackle the problem of se...

Amyloid-beta (Abeta) overproduction and dendrite arbor atrophy are hallmarks of Alzheimer's disease. The RhoA GTPase (Rho) signals through Rho kinase (ROCK) to control cytoskeletal dynamics and regulate neuron structure. Hyperactive Rho signaling destabilizes neurons leading to dendritic regression that can be rescued by genetic or pharmacological reduction of ROCK signaling. To understand what...

Residual stress and lattice defects in commercial zinc anodes are essential factors for dendrite formation during deposition as they lead to a heterogeneous limit the epitaxial growth of zinc. In their Research Article (e202218612), Haiyan Wang et al. propose an annealing strategy defect repair residual relief. As result, reconstructed anode achieved highly growth. Heritage Science Fluoridation...