نتایج جستجو برای: dendritic cell based vaccine
تعداد نتایج: 4502938 فیلتر نتایج به سال:
PURPOSE The success of cancer immunotherapy depends on the balance between effector T cells and suppressive immune regulatory mechanisms within the tumor microenvironment. In this study we investigated whether transient monoclonal antibody-mediated depletion of CD25(high) regulatory T cells (Treg) is capable of enhancing the immunostimulatory efficacy of dendritic cell vaccines. EXPERIMENTAL ...
Micro- and nanometer-size particles have become popular candidates for cancer vaccine adjuvants. However, the mechanism by which such particles enhance immune responses remains unclear. Here, we report a porous silicon microparticle (PSM)-based cancer vaccine that greatly enhances cross-presentation and activates type I interferon (IFN-I) response in dendritic cells (DCs). PSM-loaded antigen ex...
To generate an effective cellular immune response, it is necessary to elicit both antigenspecific CTL (CD8) and Th (CD4) T cell recognition. The design of an effective therapeutic vaccine must incorporate means by which to generate novel T cell responses or enhance existing responses of a clinically-preferred functional type. In the cancer setting, one vaccine strategy is to target the immune s...
Burkholderia pseudomallei, the causative agent of melioidosis, is a gram-negative bacterium which can cause either chronic infections or acute lethal sepsis in infected individuals. The disease is endemic in Southeast Asia and northern Australia, but little is known about the mechanisms of protective immunity to the bacterium. In this study, we have developed a procedure to utilize dendritic ce...
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