نتایج جستجو برای: dendrosomal curcumin

تعداد نتایج: 11144  

Journal: :Biochemical pharmacology 2004
Xiaohua Gao Jarret Kuo Hao Jiang Dorrah Deeb Yongbo Liu George Divine Robert A Chapman Scott A Dulchavsky Subhash C Gautam

Curcumin (diferuloylmethane), a major curcumanoid found in the spice turmeric, exhibits anti-inflammatory, anti-oxidant, and chemopreventive activities. However, the effect of curcumin on the development of T cell-mediated immunological responses largely remains unknown. In this study we have investigated the effect of curcumin on mitogen/antigen induced proliferation of splenic lymphocytes, in...

2014
Xiaoyan Zhu Qian Li Ruimin Chang Dong Yang Zongbing Song Qulian Guo Changsheng Huang

The management of neuropathic pain is still a major challenge because of its unresponsiveness to most common treatments. Curcumin has been reported to play an active role in the treatment of various neurological disorders, such as neuropathic pain. Curcumin has long been recognized as a p300/CREB-binding protein (CBP) inhibitor of histone acetyltransferase (HAT) activity. However, this mechanis...

Journal: :Molecular cancer therapeutics 2007
Lan Li Bilal Ahmed Kapil Mehta Razelle Kurzrock

The role of curcumin (diferuloylmethane), a proapoptotic compound, for the treatment of cancer has been an area of growing interest. Curcumin in its free form is poorly absorbed in the gastrointestinal tract and therefore may be limited in its clinical efficacy. Liposome encapsulation of this compound would allow systemic administration. The current study evaluated the preclinical antitumor act...

Journal: :Biochimica et biophysica acta 2006
Amit Kunwar Atanu Barik Ruchi Pandey K Indira Priyadarsini

Curcumin, a lipid soluble antioxidant, exhibits solvent and medium sensitive absorption and fluorescence properties. Using such changes, the average binding constants of curcumin to phosphatidylcholine (PC) liposomes and human serum albumin (HSA) were estimated to be 2.5 x 10(4) M(-1) and 6.1 x 10(4) M(-1) respectively. From the studies on temperature dependent fluorescence anisotropy of liposo...

2014
Dawn Chin Patricia Huebbe Jan Frank Gerald Rimbach Kathrin Pallauf

Curcumin has been shown to have many potentially health beneficial properties in vitro and in animal models with clinical studies on the toxicity of curcumin reporting no major side effects. However, curcumin may chelate dietary trace elements and could thus potentially exert adverse effects. Here, we investigated the effects of a 6 month dietary supplementation with 0.2% curcumin on iron, zinc...

Journal: :Carcinogenesis 2004
David W Scott George Loo

Ingestion of plant products containing the phenolic phytochemical, curcumin, has been linked to lower incidences of colon cancer, suggesting that curcumin has cancer chemopreventive effects. Supporting this suggestion at the cellular level, apoptosis occurs in human colon cancer cells exposed to curcumin. However, the mechanism is unclear, prompting this investigation to further clarify the mol...

2017
Heni Rachmawati Aditya Trias Pradana Dewi Safitri I Ketut Adnyana

This study was conducted to evaluate the potential benefit of particle reduction down to nanoscale on curcumin, a unique natural active compound facing therapeutic problems due to low solubility and permeability. In addition, the presence of TPGS as a surfactant for multiple functions on curcumin nanoparticle was addressed. Observation was focused on bioavailability enhancement after oral admin...

2011
Jui-An Lin Jenn-Han Chen Yuan-Wen Lee Chao-Shun Lin Ming-Hui Hsieh Chuen-Chau Chang Chih-Shung Wong Judy Ju-Yi Chen Geng-Chang Yeh Feng-Yen Lin Ta-Liang Chen

The aim of this study was to evaluate the effect of curcumin on morphine tolerance and the corresponding cytokine/chemokine changes. Male ICR mice were made tolerant to morphine by daily subcutaneous injection for 7 days. Intraperitoneal injections of vehicle, low-dose or high-dose curcumin were administered 15 min after morphine injection, either acutely or chronically for 7 days to test the e...

Journal: :Molecular pharmacology 2009
Jun Li Yun Wang Chaozhe Yang Pengfei Wang Denise K Oelschlager Yong Zheng De-An Tian William E Grizzle Donald J Buchsbaum Mei Wan

Jab1 (Jun activation domain binding protein 1), integrated into COP9 signalosome complex (CSN), induces protein instability of many tumor suppressors and cell cycle regulators and is therefore a novel target in cancer therapy. Curcumin, an inhibitor of Jab1/CSN-associated kinase(s), has been reported to suppress tumor growth; however, curcumin is highly hydrophobic, and this feature prevents it...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Liang Shen Hong-Fang Ji

To the Editors: The recent interesting article by Dhillon et al. (1) evaluated the clinical biological effects of curcumin against advanced pancreatic cancer. One important puzzle arising from this study involves how the biological activities are done with the precondition of the low nanogram levels of circulating curcumin (only 22-41 ng/mL were detectable in plasma even at oral dose of 8 g/d; ...

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