Background Variants in DLX3 cause tricho-dento-osseous syndrome (TDO; MIM accession no. 190320), a systemic condition with hair, nail, and bony changes, taurodontism, amelogenesis imperfecta (AI) inherited an autosomal dominant fashion. Different variants found within this gene are associated different phenotypic presentations. To date, 6 have been reported TDO. The aim of paper is to explore d...