backgrounds and aims: the protozoan parasites of the genus leishmania can be stated as the causative agents of the various clinical diseases. fetal calf serum (fcs) is the major part of the leishmania culture media, which is the most expensive ingredient in these media. the coconut water is packed with nutrients that yield an array of health benefits. materials and methods: in the present study...

background: &beta-thalassemia; is the most common monogenic disorder in human. the (ct) polymorphism at -158 upstream region of the &gammag-globin; gene and pharmacological factors such as hydroxyurea have been reported to influence &gamma-globin; gene expression and the severity of clinical symptoms of &beta-thalassemia.; methods: in the present study, 51 &beta-thalassemia; intermediate patie...

alcohol directly affects astroglial cell function, including inflammation-related activity.  and it also affects microglial cell development and function in specific ways that interfere with microglial interactions with the immune system and with neurons. neuroinflammatory processes might be involved in alcohol-induced brain damage. alcohol use, misuse and getting used to it causes different ki...

potent induction of fetal hemoglobin (hbf) production results in alleviating the complications of β-thalassemia and sickle cell disease (scd). hbf inducer agents can trigger several molecular signaling pathways critical for erythropoiesis. janus kinase/signal transducer and activator of transcription (jak/stat), mitogen activated protein kinas (mapk) and phosphoinositide 3-kinase (pi3k) are con...

our previous studies on thalassemia patients, homozygous or compound heterozygous for severe beta thalassemia mutations, has suggested that 5’hs4-lcr and/or xmn1-hbg2 backgrounds, which were linked in our thalassemia patients, are important in determining the blood transfusion dependency of these individuals. while the majority of patients with aa/-- 5’hs4/xmn1 background, were severely depende...

background several factors may cause infertility and fetal loss. blood groups antigens seem to be implied in the mechanisms of infertility and fetal loss. maternal natural antibody can react against father’s blood group antigens on spermatozoa. the effects of parental blood group system on infertility and fetal surveillance perceived by its manifestation in prezygotic (caused infertility) and p...

isolation of cell free fetal dna (cffdna) from maternal serum usually leads to very low concentrations of dna impeding further resolving through conventional methods of electrophoresis. although several protocols have been described for capillary electrophoresis (ce) of double stranded dna, they usually need using special polymers or coated capillaries which degrade over time. herein, we propos...

a true estimation of gestational age (ga) plays an important role in quality maternity care and scheduling the labor date. this study aimed to evaluate the normal fetal kidney length (kl) and its correlation with ga. a cross-sectional study on 92 pregnant women between 8th and 10th week of gestation with normal singleton pregnancy underwent standard ultrasound fetal biometry and kidney length m...

hepatic dysfunction is a frequent manifestation in patients with sickle cell anemia. it is usually a multifactorial process. a rare benign form of extreme hyperbilirubinemia, presumably due to intrahepatic sickling, may be the cause. we report a 9 year old girl with sickle-thalassemia hemoglo binopathy, presenting with profound jaundice. sickle cell disease is often mild in the iranian populati...