Several second-generation farnesoid X receptor (FXR) agonists are being developed to reproduce the histological benefit demonstrated with obeticholic acid, but an improved safety profile. MET409 is one of these novel, non-biliary FXR altered PK and PD properties that allow once daily dosing. Harrison coworkers present a proof-of-concept trial where 58 patients biopsy-proven non-alcoholic steato...

There is evidence to suggest that airborne droplets play an important role in the transmission of respiratory diseases. The highest risk exposure these pathogens indoor environments, where airflow control has been recognized as one most effective engineering means combat its spread. However, this can contribute a significant increase energy costs, conventional ventilation often not designed rem...

Mine ventilation provides fresh air to underground workers. The dampers can provide a qualified each demand workplace by adjusting the volume, which ensure workers’ health. However, powerful impact damage caused gas explosions in roadway lead deformation and even cause breakdown of system. At same time, effects may worker fatalities. For this reason, dynamic response their need be studied. Base...