Pharmacophore development, 3D-QSAR and docking studies were performed on twenty eight pyrrolotriazine derivatives as Aurora A kinase inhibitors. Five point pharmacophores with one hydrogen bond acceptor (A2), two hydrogen bond donor (D8, D11), one positive ionic (P15) and one aromatic ring (R17) as pharmacophoric features were developed. Amongst them the Pharmacophore hypothesis ADDPR.55 yielde...

We study the noncommutative version of the extended ADHM construction in the eight dimensional U(1) Yang-Mills theory. This construction gives rise to the solutions of the BPS equations in the Yang-Mills theory, and these solutions preserve at least 3/16 of supersymmetries. In a wide subspace of the extended ADHM data, we show that the integer k which appears in the extended ADHM construction s...

In this paper we find infinitely many lattices in SL(4,R) each of which contains thin subgroups commensurable with the figure-eight knot group.

We study the fermionic sector of a probe D8-brane in the supergravity background made of D4-branes compactified on a circle with supersymmetry broken explicitly by the boundary conditions. At low energies the dual field theory is effectively four-dimensional and has proved surprisingly successful in recovering qualitative and quantitative properties of QCD. We investigate fluctuations of the fe...

Using holographic QCD based on D4-branes and D8-anti-D8-branes, we have computed couplings of glueballs to light mesons. We describe glueball decay by explicitly calculating its decay widths and branching ratios. Interestingly, while glueballs remain less well understood both theoretically and experimentally, our results are found to be consistent with the experimental data for the scalar glueb...

In this work, we first derive the corrections to instanton configuration of flavored gauge field in D4--D8 model with generic flavor numbers. Then, as on D8-branes represents equivalently baryon model, keeping our hand, systemically study spectrum baryon, heavy-light or meson and find it is possible fit experimental data model. We also briefly outline how include interaction glueball correction...

The D8 jet transport configuration is presented. Focus is on the aerodynamic characteristics of its distinguishing features: the wide “double-bubble” fuselage with beneficial pitching moment and carryover lift characteristics, the nearly-unswept wing and reduced cruise Mach number, and the boundary layer ingesting rear engine installation together with the twin “pi-tail” configuration. The meri...

A theoretical analysis of a series imidazole-based Y-shaped chromophores, D1–D8, is performed in order to investigate their non(linear) optical, fluorescence, and charge-transport properties. The calculations have been carried out employing DFT TD-DFT methods at CAM-B3LYP M06-2X levels theory. FMO reveals that ground state, the highest occupied molecular orbital localized on 4,5-dimethylanilino...

REASONS FOR PERFORMING STUDY We have observed saddle slip consistently to one side because of a crooked rider, an ill-fitting saddle, asymmetry in a horse's thoracolumbar shape and lameness. Currently, there are no objective data to permit assessment of the relative importance of each factor. OBJECTIVES To document the frequency of occurrence of saddle slip in horses with hindlimb lameness co...