BACKGROUND Postoperative sore throat (POST) is a frequent complication of tracheal intubation, particularly after surgery in the prone position. We designed this study to validate the non-inferiority of magnesium sulphate against dexamethasone for prevention of POST after lumbar spinal surgery. METHODS One hundred and forty-six patients were randomly allocated to receive either magnesium or d...

Homogenates prepared from a previously established cell line derived from rabbit cornea contain a macromolecule with many properties of a glucocorticoid receptor, namely high affinity (KD = 6 x 10(-9)M) and saturable capacity (135 femtomoles/mg protein) for dexamethasone, extreme heat lability, and a pattern of competition similar to that found in other glucocorticoid target cells. Intact cells...

BACKGROUND Pain after shoulder surgery is often treated with interscalene nerve blocks. Single-injection blocks are effective, but time-limited. Adjuncts such as dexamethasone may help. We thus tested the hypothesis that adding dexamethasone significantly prolongs the duration of ropivacaine and bupivacaine analgesia and that the magnitude of the effect differs among the two local anaesthetics....

BACKGROUND Controlling postoperative pain and vomiting in children remains a great challenge. OBJECTIVE Study the efficacy of adding dexamethasone to caudal bupivacaine on postoperative analgesia and vomiting. STUDY DESIGN Prospective, randomized double blind controlled clinical trial. SETTING Assiut University Hospital. PATIENTS Ninety children ASA I-II, undergoing lower orthopedic sur...

We have studied the effects of dexamethasone on cell growth and DNA synthesis in the A549 cell line, a line that was originally isolated from a human alveolar carcinoma. Dexamethasone at a concentration of 10 9 M inhibited growth of these cells. Maximal growth inhibition was seen with 4 x 10 " M dexamethasone (44% of control). The population-doubling time of the cells increased from 28.4 hr und...

IGF-I stimulation of cell proliferation and c-Fos expression in skeletal muscle cells is markedly enhanced by dexamethasone. The effect of dexamethasone is not mediated by changes in IGF-binding proteins, as evidenced by similar effects of dexamethasone on the actions of insulin, PDGF-BB, and the IGF-I analogue long R3IGF-I. Dexamethasone also does not alter autocrine IGF-II secretion by muscle...

Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) is a mitogen and chemotactic factor for endothelial cells in vitro and an angiogenesis and vascular permeability factor in vivo. Due to its properties, VEGF is a candidate for both angiogenesis and vascular permeability/oedema induction which typically occur in glioblastomas. In this study we test the hypothesis that the...

Haematological toxicities and thromboembolic (TE) events are common complications of myeloma therapy. TE risk may be elevated with combination regimens, notably thalidomide/lenalidomide plus high-dose dexamethasone; concomitant erythropoietin appears to further increase the risk with lenalidomide-dexamethasone. We characterised thrombocytopenia and neutropenia in the phase 3 APEX (Assessment of...

Context: To measure central macular thickness (CMT) in diabetic patients after instilling intracameral dexamethasone at the end of cataract surgery and compare this measure with control group. Design: Prospective case-control study. Participants: 100 eyes of 100 diabetic patients undergoing cataract extraction. Methods: 50 eyes received intracameral dexamethasone 0.4mg/0.1ml at the end of surge...