Delayed puberty, while not uncommonly a variant of normal pubertal physiology, could be an indicator of a wide range of less common but important clinical disorders. Congenital pathologies may involve defective developments of the gonads, pituitary gonadotrophs or hypothalamic GnRH neurons. Acquired pathologies could likewise be acting at each level. Clinical diagnostic evaluation to delineate ...

Background Cardiac Amyloidosis (CA) is an important prognostic indicator in patients with systemic amyloidosis. Cardiac MRI has emerged as imaging modality of choice to evaluate patients with CA. Delayed hyper-enhancement cardiac magnetic resonance (DHE-CMR) provides incremental diagnostic and prognostic utility in suspected CA. We performed a meta-analysis to evaluate the prognostic role of LG...

In the midst of frequent reports about "the asthma epidemic," results from a number of studies by the manitoba centre for health policy have shown stable or decreasing prevalence of an overall indicator of respiratory diseases which includes asthma. To resolve these apparently contrary findings, we conducted a time trend analysis using administrative data. results revealed significant potential...

We describe a simple initial indicator of whether a proposed merger between rivals in a differentiated product industry is likely to raise prices through unilateral effects. Our diagnostic calibrates upward pricing pressure (UPP) resulting from the merger, based on the price/cost margins of the merging firms’ products and the extent of direct substitution between them. As a screen for likely un...

Treacher Collins syndrome (Mandibulofacial dysostosis) is characterized by deafness, hypoplasia of facial bones (mandible, maxilla and cheek bone), antimongoloid slant of palpebral fissures, coloboma of the lower lid and bilateral anomalies of the auricle. Hypoplasia of the facial bones may be the first indicator of the disorder. We present a case report of Treacher Collins syndrome with their ...

We have used a combination of stellar population synthesis and photoioniza-tion models to develop a set of ionization parameter and abundance diagnostics based only on the use of the strong optical emission lines. These models are applicable to both extragalactic H II regions and star-forming galaxies. We show that, because our techniques solve explicitly for both the ionization parameter and t...

Gastrointestinal bleeding is a common occurrence in patients with cancer and is a frequent indicator of a gastrointestinal malignancy. Rapid evaluation and treatment is key for the hemodynamically unstable patient. Endoscopy remains the cornerstone of diagnosis and management for cancer patients with gastrointestinal bleeding. The emergency physician should also be aware of other diagnostic and...