• Atypical hemolytic uremic syndrome (aHUS) is a disease characterized by chronic, uncontrolled complement activation and thrombotic microangiopathy (TMA), leading to renal and other end organ damage • Plasma exchange/plasma infusion (PE/PI) provides limited clinical benefit to children with aHUS— 29% progress to end-stage renal disease or die within the first year of diagnosis.1,2 PE/PI is als...

Hypertonic and hyperoncotic solutions are generally used as acute treatment for symptomatic hypotension during dialysis. Administration of hydroxyethylstarch (HES) was recently shown to be an effective substitution fluid in preserving blood volume (BV) and systolic BP (SBP) in a group of stable dialysis patients during dialysis. In this study, in nine cardiac-compromised dialysis patients with ...

BACKGROUND High blood pressure is a common condition in hemodialysis patients. Uric acid, which is high in these patients due to decreased clearance, had been shown to positively correlate with blood pressure in animal studies. OBJECTIVES The goal of this investigation was to evaluate the impact of high uric acid level on blood pressure in these patients. PATIENTS AND METHODS Ninety-one pat...

Nephrology fellows often face difficult conversations about dialysis initiation or withdrawal but are frequently unprepared for these discussions. Despite evidence that communication skills are teachable, few fellowship programs include such training. A communication skills workshop for nephrology fellows (NephroTalk) focused on delivering bad news and helping patients define care goals, includ...

In a prospective randomized controlled study, the efficacy and safety of a continuous ambulatory peritoneal dialysis (CAPD) technique has been evaluated using one icodextrin-containing and two glucose-containing dialysates a day. Eighty incident CAPD patients were randomized to two groups; GLU group continuously using four glucose-containing dialysates (n=39) and ICO group using one icodextrin-...

INTRODUCTION Early prediction of the efficacy of treatment in peritonitis complicating peritoneal dialysis (PD) is the best way to reduce morbidity. We studied the prognostic value of the third-day dialysis effluent leukocyte count after antibiotic therapy for prediction of treatment outcomes. MATERIALS AND METHODS Medical records of 31 children on PD, younger than 15 years old, admitted in A...

Background:Dialysis is a process for eliminating extra uremic fluids of patients with chronic renal failure. The present study aimed to determine the variables that influence the survival of dialysis patients using random survival forest model (RSFM) in low-dimensional data with low events per variable (EPV). Methods:In this historical cohort study, infor...

BACKGROUND Ferric citrate (FC) is a phosphate binder in development for the treatment of hyperphosphatemia in patients with end-stage renal disease (ESRD). In clinical trials, FC improved patient serum phosphorus levels and increased serum ferritin and percent transferrin saturation. Because nephrologists respond to increases in these iron measures by reducing intravenous (IV) iron and erythrop...