A general approach to 6-phenylthio-substituted 2,3,4,5-tetrahydro-1H-1,3-diazepin-2-ones based on the ring expansion reaction of 1,2,3,4-tetrahydropyrimidin-2-ones under the action of nucleophiles has been developed. The first step of the synthesis was preparation of N-[(2-benzoyloxy-1-tosyl)ethyl]urea by three-component condensation of 2-benzoyloxyethanal, urea and p-toluenesulfinic acid. Nucl...

In the title mol-ecular salt, C5H8N3(+)·C3H3O4(-), the cation is essentially planar, with a maximum deviation of 0.005 (1) Å for all non-H atoms. In the anion, an intra-molecular O-H⋯O hydrogen bond generates an S(6) ring. In the crystal, the cations and anions are connected via N-H⋯O hydrogen bonds and a weak C-H⋯O inter-action, forming layers parallel to the ab plane.

In the title compound, C(6)H(9)NO(4), which is an example of a push-pull alkene, N-H⋯O inter-actions stabilize the crystal structure.

Herein we report the first example of Pd-catalyzed highly selective three-component reaction alkyn-1,4-diol dicarbonates, organoboronic acids, and malonate anions for efficient synthesis trisubstituted 2,3-allenyl malonates not readily...

In the present study the synthesis of Fluoroquinolone nucleus, 7-chloro-6-fluoro-1, 4dihydro-4-oxoquinoline-3-ethyl carboxylate has been reported by the microwave-assisted condensation of 3-chloro-4-fluoro aniline and diethyl (ethoxymethylene) malonate (EMME) under solvent free conditions. The microwave-assisted synthesis of Fluoroquinolone nucleus was successfully standardized and optimized ma...

Treatment of 2,3-diaryloxirane-2,3-dicarbonitriles 1a-c with different nitrogen nucleophiles, e.g., hydrazine, methyl hydrazine, phenyl hydrazine, hydroxylamine, thiosemicarbazide, and/or 2-amino-5-phenyl-1,3,4-thiadiazole, afforded pyrazole, isoxazole, pyrrolotriazine, imidazolothiadiazole derivatives 2-5, respectively. Reacting pyrazoles 2a-c with aromatic aldehydes and/or methyl glycinate pr...

Leaves and leaf slices from Aloe arborescens Mill. were used to study the interrelations between Crassulacean acid metabolism, photosynthesis, and respiration. Oxygen exchange of leaf slices was measured polarographically. It was found that the photosynthetic utilization of stored malic acid resulted in a net evolution of oxygen. This oxygen production, and the decrease in acid content of the l...

We describe the first example of manganese(III)-catalyzed aerobic dehydrogenative cyclization producing ring-fused indole skeletons. This catalytic system converts from two C-H bonds of indole and malonate to a C-C bond and produces water as the sole side product. This operationally easy method was extended to an intermolecular cross-dehydrogenative coupling of indole and α-substituted malonate...

In the title compound, C(15)H(15)NO(4), the quinoline ring system and one of the malonate side chains are essentially coplanar (r.m.s. deviation = 0.0297 Å). The two malonate C-C(=O)-O-CH(3) side chains are oriented at right angles [89.68 (8)°] with respect to each other. The crystal packing is stabilized by weak non-classical inter-molecular C-H⋯O hydrogen bonds, which link the mol-ecules into...