the LCLINK-D assembly. The sluggishness of the VHICH1-LINK-D reaction may be caused by formation of strong secondary structures within the coding region of CHI, which would also account for the relatively weaker amplification of the Fd gene (as compared to the VH gene) as observed previously (9). Although the PCR assembly strategy has been described as somewhat difficult (4), we find it an attr...

résumé – Détection du fonctionnement différentiel d’items par régression logistique La régression logistique a été utilisée comme une méthode d’identification du DIF dans différents contextes. Certaines études ont montré que cette procédure peut être affectée par des variables comme le ratio des tailles entre groupes, la taille de l’échantillon, et qu’elle semble liée avec les gammes de difficu...

We study statistical methods to detect cancer genes that are over- or down-expressed in some but not all samples in a disease group. This has proven useful in cancer studies where oncogenes are activated only in a small subset of samples. We propose the outlier robust t-statistic (ORT), which is intuitively motivated from the t-statistic, the most commonly used differential gene expression dete...

Deep transcriptome sequencing (RNA-Seq) has become a vital tool for studying the state of cells in the context of varying environments, genotypes and other factors. RNA-Seq profiling data enable identification of novel isoforms, quantification of known isoforms and detection of changes in transcriptional or RNA-processing activity. Existing approaches to detect differential isoform abundance be...

A multiple-symbol differential detector is formulated for -ary differential phase-shift keying modulation where the channel state information is unknown to the receiver. The maximum-likelihood decision statistic is derived for the detector, and its performance is demonstrated by analysis and simulation. Under the Gaussian assumption for the aggregate interference plus noise, an exact expression...

This paper looks at capacity achieving detection strategies for information transfer over time-varying channels. The time-varying binary symmetric channel (TV-BSC) is identified as the basic binary state-space model. Separation of entropies principles and the TV-BSC model-based state-space approach are used to determine the performance bounds for coherent and non-coherent detection over time-va...