Background. The aims of this study were to analyze the clinical characteristics of SPM in patients with well-differentiated thyroid cancer and to determine the long-term prognosis in patients with double malignancies. Materials and Methods. We retrospectively analyzed 2,864 patients with well-differentiated thyroid cancer and a mean age of 44.0 ± 14.4 years. Of these, 200 (7.0%) were diagnosed ...

OBJECTIVE Fluorodeoxyglucose positron emission tomography/computed tomography imaging in the follow-up of patients with differentiated thyroid carcinoma who have high serum thyroglobulin, negative iodine-131 whole body scan and suppressed thyrotropin. PATIENTS AND METHODS A total of 90 patients (31 male and 59 female) with differentiated thyroid carcinoma who have high serum thyroglobulin and...

Most of the TSH effects on the proliferation and differentiation of thyroid cells are mediated by cAMP via an adenylyl cyclase-activating Gs protein. TSH receptor responsiveness in cell cultures, is regulated by G protein-coupled receptor kinase (GRK) 2 and 5. To determine whether an alteration in activity and expression of GRKs might be associated with variable levels of TSH receptor desensiti...

as the fifth most expected malignancy in American women. Although thyroid cancer is not infrequently diagnosed, it rarely bests its host. We understand a great deal about well-differentiated thyroid cancers, including carcinomas of the thyrocyte and parafollicular c-cells. We have identified a number of mutations and gene rearrangements responsible for familial and sporadic tumors. We have post...

OBJECTIVE Thyroid hemiagenesis is a rare congenital disorder characterized by the absence of a lobe and/or of isthmus. Studies on the association between thyroid hemiagenesis, Graves' disease and differentiated thyroid cancer are rare. CASE PRESENTATION We describe the medical and surgical history of a patient in whom a molecular evaluation was performed. A 36-year-old man presented with symp...

OBJECTIVE To present the case of a radioiodine therapy-naïve thyroid cancer patient with postthyroidectomy diplopia. CLINICAL PRESENTATION AND INTERVENTION A 63-year-old male patient presented with goiter. Histology performed after thyroidectomy proved follicular thyroid cancer. Without (131)I therapy, diplopia occurred from metastasis to the right medial rectus muscle. Improvement followed a...

introduction:  in order to assess echocardiographic left ventricular functional indices in patients with differentiated thyroid carcinoma (dtc), after l-t4 withdrawal (short-term overt hypothyroidism) and during tsh suppressive therapy, we have evaluated cardiac hemodynamics in a single cohort study. methods: 24 patients with dtc were studied in two phases: 1: at least 4 weeks after l-t4 withdr...

Primary thyroid cancers including papillary, follicular, poorly differentiated, and anaplastic carcinomas show substantial differences in biological and clinical behaviors. Even in the same pathological type, there is wide variability in the clinical course of disease progression. The molecular carcinogenesis of thyroid cancer has advanced tremendously in the last decade. However, specific inhi...

The meaning of nodal metastases in well-differentiated thyroid carcinoma is controversial. The Authors analyse the impact of lymphatic spread reviewing 1503 cases of well-differentiated thyroid carcinoma treated at the National Cancer Institute of Rome between 1988 and 2005, in order to detect significant prognostic factors through multivariate analysis. Overall, 462 cases of locally advanced w...

Thyroid carcinoma is uncommon but accounts for roughly 95% of all cancers of the endocrine system (1). The "well-differentiated" thyroid tumors include the papillary, follicular, and Hurthle cell subtypes. Although the management of these tumor types generally is similar, important diagnostic and clinical differences do exist (2). We present a case of follicular thyroid carcinoma with spinal me...