Cancers evolve as a result of the accelerated proliferation cancer cells in complicated, enriched, and active microenvironment. Tumor microenvironment (TME) components are master regulators any step development. The tumor is composed many cellular noncellular that contribute to evolution cells. Cancer-associated fibroblasts (CAFs) activated TME implicate progression metastasis dissemination thr...

Background/Aim. About 10% of patients diagnosed with systemic cancer leads to the appearance brain metastases in central nervous system. Diseased lungs, breasts, urinary and digestive tract as well melanoma skin, are increasingly treated by neurosurgeons due their dissemination creation secondary deposits brain. Methods. The retrospective study was performed at Clinic for Neurosurgery Oncology ...

BACKGROUND & AIMS There is high need of novel diagnostic and prognostic tools for tumors of the digestive system, such as gastric cancer and cholangiocarcinoma. We recently found that miR-204 was deeply downregulated in gastric cancer tissues. Here we investigated whether this was common to other tumors of the digestive system and whether this elicited a miR-204-dependent gene target signature,...

There is growing interest in the use of natural compounds such as phytochemicals medicine. Turmeric known to possess many health benefits and has been used for centuries culinary traditional uses. Its most potent phytochemical, curcumin, subject extensive research andexhibits biological activities, including anti-cancer activities. However, it not approved therapeutic due poor bioavailability. ...

Purpose MHC class I chain related-proteins A (MICA) and B (MICB) are natural killer group 2D ligands that mediate tumor surveillance. Several studies have suggested that MICA/B levels predict clinical outcomes in patients with cancer; however, this remains contentious. Here, we present a systematic review and meta-analysis of available studies of the prognostic value of MICA/B in cancer. Mate...

BACKGROUND Dairy food and calcium intakes have been hypothesized to play roles that differ among individual cancer sites, but the evidence has been limited and inconsistent. Moreover, their effect on cancer in total is unclear. METHODS Dairy food and calcium intakes in relation to total cancer as well as cancer at individual sites were examined in the National Institutes of Health (NIH)-AARP ...

Four hundred and seventy eight (478) individuals who exhibited some manifestation of chronic and debilitating illness including persistent cough, skin cancer and dermatitis, multiple lymph adenitis, diarrhea and enteritis, genital sore, urethritis, vaginitis and weight loss, were examined to establish relationships between human immunodeficiency virus infection (HIV) and digestive tract pathoge...

background: the nigella sativa l. seeds have been used as herbal medicine in several countries for the treatment and prevention of a wide range of diseases like cough and bronchial asthma, headache, nasal congestion, toothaches, intestinal worm, menstrual disorder, digestive abnormality, and impotence. objective: the aim of this review was to collect updated available data focused on the pharma...