In majority of the cases familial dilated cardiomyopathy (DCM) is inherited in an autosomal dominant manner. In rare instances, this condition is inherited in an autosomal recessive pattern. In other rare cases, DCM can be inherited in an Xlinked pattern. Establishing a genetic diagnosis confirms or modifies the clinical diagnosis and enables disease specific estimates on prognostics and treatm...

A 28-year-old male patient with bipolar disorder taking olanzapine and lorazepam for almost 10 years presented with weight gain, diabetes, and anasarca was examined in this study. Evaluation of the patient revealed he was in heart failure. The reason for his heart failure was ambiguous and an investigation into it revealed negative results. Literature search conducted showed a few reported case...

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Background. X-linked cardiomyopathy (XLCM) is a rapidly progressive primary myocardial disorder presenting in teenage males as congestive heart failure. Manifesting female carriers have later onset (fifth decade) and slower progression. The purpose of this study was to localize the XLCM gene locus in two families using molecular genetic techniques. Methods and Results. Linkage analysis using 60...

Objective: In dilated cardiomyopathy and in athlete’s heart, progressive LV dilatation is accompanied by rightward displacement of thediastolic LV pressure–volume relation. In dilated cardiomyopathy, an increase in diastolic LV stiffness can limit this rightwarddisplacement thereby decreasing LV systolic performance. Because nitric oxide (NO) reduces diastolic LV stiffness, the present ...

Objective To identify the clinical and laboratory predictors of short-term mortality in patients with acute heart failure (AHF). Subjects and methods We conducted a prospective, single center study on 120 consecutive patients presented with acute heart failure to the emergency department. All patients had clinical, laboratory, electrocardiographic and echocardiographic evaluation. Short-term ...

A 30-year-old-man who initially presented three years previously to the emergency department with right loin pain and a three-month history of haematuria. He reported no other urinary symptoms and was otherwise fit and well with no significant past medical history. Flexible cystoscopy was unremarkable and evaluation with ultrasound and a computed tomography (CT) scan demonstrated a large right-...

Background—Ventricular activation is often abnormal in patients with dilated cardiomyopathy, but its specific eVects on timing remain undetermined. Objective—To investigate the use of the ratio of the sum of left ventricular ejection and filling times to the total RR interval (Z ratio) to dissociate the eVects of abnormal activation from those of cavity dilatation. Methods—Subjects were 20 norm...

Five patients with only mildly dilated ventricles but other features typical of congestive cardiomyopathy underwent cardiac transplantation for class IV NYHA heart failure. The findings of clinical studies, cardiac catheterization, endomyocardial biopsy, and pathologic examination of the removed hearts in this group with mildly dilated congestive cardiomyopathy (MDCM) were compared with similar...

Dilated cardiomyopathy (DCM) is primary disease of the muscle of the heart, characterized by a progressive decline in the contractility of the ventricles, dilation of all the cardiac chambers, leading to congestive heart failure (CHF), arrhythmias, and death. Histopathology of the cardiac muscle (myocardium) reveals necrosis of cardiac cells, scar tissue (fibrosis), and sometimes replacement of...