BACKGROUND Linagliptin is an oral antihyperglycemic agent that selectively inhibits the enzyme dipeptidyl peptidase-4 (DPP-4). Inhibition of DPP-4 increases the levels of the incretin hormones glucagon-like peptide and glucose-dependent insulinotropic polypeptide by preventing their degradation. OBJECTIVE We reviewed the role of linagliptin as an oral once-daily treatment for patients with ty...

Incretin-based therapies such as glucagon-like peptide-1 (GLP-1) receptor agonists (RA) and dipeptidyl peptidase-4 (DPP-4) inhibitors have gained prominence in recent years for the treatment of type 2 diabetes (T2D). Such therapies offer the potential to stimulate endogenous insulin activity in proportion to circulating glucose levels; thereby, lowering the risk of hypoglycemic episodes. The sy...

OBJECTIVES To evaluate glycaemic durability with dipeptidyl peptidase-4 (DPP-4) inhibitors in type 2 diabetes. DESIGN A systematic review and meta-analysis of long-term randomised trials of DPP-4 inhibitors on haemoglobin A1c (HbA1c) was conducted. Electronic searches were carried out on the following databases: MEDLINE, EMBASE, Scopus and Web of Knowledge to December 2013. Searches were supp...

Incretin based therapies have been introduced into the treatment options of type 2 diabetes a few years ago. Among them, the orally active DPP-4 inhibitors have established themselves as insulinotropic agents. Their advantage is the glucose-dependent insulinotropic action without an intrinsic risk for causing hypoglycemia. Additionally DPP-4 inhibitors have a glucose dependent glucagonostatic a...

Dalam tatalaksana diabetes melitus tipe 2, terapi kombinasi dua obat antidiabetik disarankan jika dengan monoterapi gagal mencapai target kontrol glikemik. Pemilihan jenis tergantung kondisi pasien dan profil obat. Kombinasi oral golongan penghambat DPP-4 (dipeptidyl peptidase-4) SGLT-2 (sodium-glucose cotransporter type 2) dapat menjadi salah satu pilihan.
 Combination of two antidiabetic...

Type 1 diabetes (T1D) and latent autoimmune in adults (LADA) represent the most common types of are characterized by different age onset, degrees immune-mediated destruction pancreatic beta cells rates disease progression towards insulin dependence. Several immunotherapies aimed to counteract responses against preserve beta-cell function currently being investigated, particularly T1D. Prelimina...