Meningiomas are tumors derived from arachnoid cap cells that represent approximately 30% of all intracranial tumors. In this study, we investigated 22 human meningiomas for the expression of dipeptidyl peptidase (DPP)-IV activity and/or structure homologs (DASH), including canonical DPP-IV/CD26, fibroblast activation protein-alpha (FAPalpha), DPP8 and DPP9. DPP-IV-like enzymatic activity, inclu...

Abbreviations ACCORD Action to Control Cardiovascular Risk in Diabetes ADVANCE Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation AGI α-Glucosidase inhibitor CAD Coronary artery disease CKD Chronic kidney disease CVD Cardiovascular disease DPP-4 Dipeptidyl peptidase IV GIP Glucose-dependent insulinotropic peptide GLP-1 Glucagon-like peptide 1 ...

Abstract The hydrolysate of Oncorhynchus keta (chum salmon) milt was found to exhibit strong inhibitory activity against dipeptidyl peptidase-IV (DPP-IV), and the hypoglycaemic effect these salmon peptides (SMPs) confirmed using oral starch tolerance tests in Sprague–Dawley rats. Specifically, administration SMPs at a dose 300 mg/kg body weight for 1 week resulted significant decrease blood glu...

A number of functional foods containing seaweed-derived peptides are currently commercialized. Some seaweed derived peptide-containing products include Wakame peptide® and Nori peptide S®. To develop with the addition Ulva spp. peptides, isolation identification dipeptidyl peptidase IV (DPP-IV) inhibitory from hydrolysates this was performed. were fractionated purified sequentially by anion exc...

Proteins and peptides of housefly larvae (HFL) have potential applications in food therapy. The fate HFL proteins following human gastrointestinal (GI) digestion is unknown. This study adopted a computational approach to discover released from upon GI digestion. In silico eight major 783 peptides. comprised 243 exhibiting 13 types bioactivities. Ninety-two single-function anti-dipeptidyl peptid...

246 Introduction: 469 Discussion: 1447 References: 24 Tables: 6 Figures: 11 Abbreviations: DPP-IV, dipeptidyl peptidase IV; GLP-1 glucogen-like peptide 1; PF-00734200, 3,3-Difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2yl)methanone, ESI, electrospray ionization; HFAA, hexaflouroacetylacetone; SD, Sprague Dawley; GLP-1, glucagon like peptide; FAP, fibroblast act...

Drug treatment of 2 diabetes is intended to normalize glycosylated hemoglobin levels (HbA(1c)<6.5%) and thereby prevent the development of micro- and macrovascular complications. Oral antidiabetic agents target the metabolic abnormalities that cause diabetes. The two principal families of oral antidiabetic agents - insulin sensitizers and insulin secretagogues - can be taken together. Thiazolid...