OBJECTIVE To evaluate the use of a point-of-care transcutaneous bilirubinometer, JM-103 Minolta, for estimation of the serum bilirubin level in the management of neonatal jaundice in term or near-term Chinese neonates. DESIGN Prospective correlation study. SETTING Accident and Emergency Department of a regional hospital in Hong Kong. PATIENTS All term or near-term Chinese neonates aged 3 ...

BACKGROUND Routine repeat testing of critical laboratory values is very common these days to increase their accuracy and to avoid reporting false or infeasible results. We figure that repeat testing of critical laboratory values has any benefits or not. METHODS We examined 2233 repeated critical laboratory values in 13 different hematology and chemistry tests including: hemoglobin, white bloo...

background & objectives: the present investigation was designed to evaluate the post-treatment properties of the hydroalcoholic fruit extract of cassia fistula (golden shower tree) in male albino mice. materials & methods: biomarkers and histological liver and kidney alterations, aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosphatase (alp), γ-glutamyl tra...

Background Hyperbilirubinemia is a common postoperative complication. Elevated direct bilirubin (D-Bil) and indirect bilirubin (I-Bil) levels are related to different pathophysiologies; therefore, their associations with outcomes also differ. However, there have been few comparative studies of such associations in postoperative patients. Methods This retrospective study compared the associati...

BACKGROUND Cognitive functions are impaired in patients with liver disease. Bile duct ligation causes cholestasis that impairs liver function. This study investigated the impact of cholestasis progression on the acquisition and retention times in the passive avoidance test and on the locomotor activity of rats. METHODS Cholestasis was induced in male Wistar rats by ligating the main bile duct...

Background: Hyperbilirubinemia is considered one of the most prevalent problems in newborns. Phototherapy, exchange transfusion, and herbal medicine are common therapeutic approaches for preventing any neurologic damage in infants with neonatal jaundice. However, herbal medicine is less commonly used. Aim: This study aimed to investigate the effect of bilineaster drop on neonatal hyperbilirubin...

Background: Hepatic dysfunction in the cancer Dept has a significant impact on patient outcomes. The therapeutic application of Anthracycline antibiotics is limited by side-effects mainly chronic Cardiotoxicity, Myelosuppression, and Hepatotoxicity. Aim: To Analyse the risk of Hepatotoxicity in Breast cancer patients receiving Inj. Doxorubicin. Subjects and Methods: The investigation was a pros...

Drug induced liver injury (DILI) can result either from dose-dependent direct hepatotoxicity or from an unpredictable dose-independent idiosyncratic reaction. Incidence of idiosyncratic DILI is estimated to be approximately 10-15 per 100,000 patient years. Here we report an extremely rare case of metronidazole induced delayed immune-allergic hepatocellular liver injury masquerading as autoimmun...

The analysis of pediatric serum for total cholesterol in the presence of high amounts of bilirubin presents special problems. The serum specimens are so small that a direct microor ultramicromethod has to be used, and consequently the error owing to bilirubin is impressive. In the proposed method, cholesterol is precipitated, along with other serum lipids, from only 20 .iliters of serum as a de...

Background: Hyperbilirubinemiais a common problem in newborn infants. It can progress to kernicterus in severe forms, unless an intervention is initiated. The objective of this study was to compare the efficacy of Clofibrate with Phenobarbital in full-term neonates with nonhemolytic jaundice. Methods: this double blind clinical trial study was performed on 60 neonate who were divided randomly i...