straightforward in terms of good manufacturing practice requirements than are wet granulation and dry compaction, the pharmaceutical industry is focusing increasingly on this process. Although coarse microcrystalline cellulose (MCC) grade 12 offers outstanding flow properties, the most commonly used grade for direct compression is the well-known fine grade 102. The reason for this preference is...

Valsartan is a FDA approved drug for the treatment of hypertension belongs to a class of drug known as angiotensin II receptor antagonists, which helps to control high blood pressure. Angiotensin II is a substance in the body that increases blood pressure. Valsartan works by blocking the effect of angiotensin II, as a result, blood vessels relaxes and blood pressure is lowered. The aim of the p...

While modern hardware can provide vast amounts of inexpensive storage for biological databases, the compression of nucleotide sequence data is still of paramount importance in order to facilitate fast search and retrieval operations through a reduction in disk traffic. This issue becomes even more important in light of the recent increase of very large data sets, such as metagenomes. In this ar...

The objective of this study was to investigate the effects of conventional lubricants including a new candidate lubricant on binary direct compression mixtures. Magnesium stearate (MGST), stearic acid (STAC), glyceryl behenate (COMP) and hexagonal boron nitride (HBN) were tested. The binary mixtures were 1:1 combinations of spray dried lactose (FlowLac 100), dicalcium phosphate dihydrate (Emcom...

The objective of the current study was to develop and optimize a sublingual tablet formulation of captopril which is an effective drug in the treatment of hypertension. Captopril containing tablets were prepared by direct compression method using different ingredients such as polyvinyl pyrrolidone, starch 1500, sodium starch glycolate and lactose (independent variables) and magnesium stearate, ...

PURPOSE The aim of this study was to design, formulate and physicochemically evaluate effervescent ranitidine hydrochloride (HCl) tablets since they are easily administered while the elderly and children sometimes have difficulties in swallowing oral dosage forms. METHODS Effervescent ranitidine HCl tablets were prepared in a dosage of 300 mg by fusion and direct compression methods. The powd...

Purpose: To evaluate a weakly cationic exchange poly(methacrylic acid-co-divinylbenzene) resin (PMD) as a new filler-binder for direct compression tablets. Methods: Powder properties of PMD and MCC were characterized. Tablets made from PMD and MCC with and without propranolol hydrochloride were evaluated for diameter, thickness, friability, assay, disintegration, dissolution and compression beh...

Sequence representations supporting not only direct access to their symbols, but also rank/select operations, are a fundamental building block in many compressed data structures. Several recent applications need to represent highly repetitive sequences, and classical statistical compression proves ineffective. We introduce, instead, grammar-based representations for repetitive sequences, which ...

The aim of this study was to prepare fast-dissolving tablets of meloxicam after its complexation with β-cyclodextrin (β-CD) and to investigate the effect of using different superdisintegrants on the disintegration and release of meloxicam from the tablets. A complex of meloxicam with β-CD was prepared by spray drying and then compressed in the form of tablets utilizing the direct compression te...