The role of microsomal cytochrome b5 (Cyb5) in defining the rate of drug metabolism and disposition has been intensely debated for several decades. Recently we described mouse models involving the hepatic or global deletion of Cyb5, demonstrating its central role in in vivo drug disposition. We have now used the cytochrome b5 complete null (BCN) model to determine the role of Cyb5 in the metabo...

OBJECTIVE Aspirin administered orally is one of most widely self-prescribed drugs to treat headaches or other pains. The aim of this study was to evaluate whether the influence of different beverages may be used to help in the ingestion of an aspirin tablet on the pharmacokinetic parameters of this drug. METHOD This study was undertaken in five healthy volunteers. Seven beverages were tested:...

This research is motivated by the lack of public awareness importance affective aspects in world education, especially mathematics. In mathematics, a positive attitude towards mathematics which includes self-confidence, flexibility, persistence, curiosity and appreciation role called mathematical disposition. One internal factors that influence disposition Advesity Quotient (AQ) has three level...

We assess the psychophysiological characteristics underlying the disposition effect and find that subjects showing greater disposition effect are those who sweat more and present lower body temperature and heart rate.

BACKGROUND Consultation is a common and important aspect of emergency medicine practice. We examined the frequency of consultations, the level of agreement and factors of disagreement with regard to the disposition of patients who visited two emergency departments (EDs) of tertiary care hospitals in Japan. FINDINGS We analyzed 3,503 consecutive patients who visited two EDs in Japan during a 3...

no volition has any moral value except as it is determined by a preceding moral principle or disposition—a moral spontaneity; and of course it is applicable to bad as well as good acts of choice. Let us then read the foregoing utterance in relation to bad acts of choice: This is the general notion, not that principles derive their badness from actions, but that actions derive their badness from...

The aim of this study was to explore the relationships among study engagement, learning adaptability, and time management disposition in a sample of Chinese baccalaureate nursing students. A convenient sample of 467 baccalaureate nursing students was surveyed in two universities in Tianjin, China. Students completed a questionnaire that included their demographic information, Chinese Utrecht Wo...

OBJECTIVE To determine if time to disposition decisions for emergency department (ED) patients can be reduced when blood tests are processed using point-of-care (POC) devices and to conduct a cost-effectiveness analysis of POC compared with laboratory testing. METHODS This randomised trial enrolled adults suspected of an acute coronary syndrome or presenting with conditions considered to only...

AIMS To investigate the relationship between adiposity and plasma free fatty acid levels and the influence of total plasma free fatty acid level on insulin sensitivity and β-cell function. METHODS An insulin sensitivity index, acute insulin response to glucose and a disposition index, derived from i.v. glucose tolerance minimal model analysis and total fasting plasma free fatty acid levels we...