The pharmacologic variability of nucleoside reverse transcriptase inhibitors such as lamivudine (3TC) includes not only systemic pharmacokinetic variability but also interindividual differences in cellular transport and metabolism. A modeling strategy linking laboratory studies of intracellular 3TC disposition with clinical studies in adolescent patients is described. Data from ex vivo laborato...

the relation between ethics and human good and evil attributes and his nature is among the age-old discourses in the field of practical philosophy (wisdom). since long ago, it has been of concern to the learned and the philosophers as to whether all ethics or a part of it in all human beings or in some of them is optional and acquired or non-optional, unacquirable, and unchangeable. this writin...

BACKGROUND Many patients are admitted to acute-care hospitals when their medical needs might be more appropriately met in an extended-care facility (ECF). OBJECTIVE To describe a cohort of patients who were admitted from an emergency department to an ECF. DESIGN Observational cohort study. PARTICIPANTS 121 enrollees of Harvard Vanguard Medical Associates who were admitted directly from an...

BACKGROUND Fertility patients often struggle with decisions about disposition of embryos remaining after fertility treatment. We aimed to identify predictors and correlates of decisional conflict among patients facing these decisions. METHODS We analyzed results from a survey of 2210 patients from nine geographically diverse US fertility clinics. The main outcome measure was decisional confli...

Three different functionalities have been incorporated into mesoporous materials by means of a coupling reaction with the siloxanes 3-glycidoxypropyl-trimethoxysilane (GLYMO), 3-methacryloxypropyl-trimethoxysilane (MEMO), and 3-mercaptopropyl-trimethoxysilane (MPTMS). The disposition functional groups, as well interaction mechanism, substrate has identified. amount antiviral drug acyclovir (ACV...

talking about paganism (jāhiliyya) is in fact a discourse about a procedure that is not limited to a specific time, since paganism is a social mode (disposition), which can appear in any time and space and has its own characteristics, goals, and standards; a reality that the holy qur’ān, the sunna of the prophet (s.a.w.), as well as the researchers’ inquiries have emphasized. the holy qur’ān ha...

this study was designed to evaluate pharmacokinetics of sulphadimidine   in cockerels fed on subclinical dose of arsenic (100 ppm) in diet and to determine the protective efficacy following simultaneous dietary medication with piper longum (pipli)   (100 ppm) in a 12-week feeding trial. pharmacokinetic parameters were determined after single i.v. dose (50 mg/kg) of sulphadimidine in cockerels i...

The present study was planned to investigate the disposition kinetics of levofloxacin in plasma of female native Barky breed sheep after single intravenous (IV) and intramuscular (IM) administration of 4 mg/kg body weight. The concentrations of levofloxacin in the plasma were measured using high-performance liquid chromatography (HPLC) with a UV detector on samples collected at 0, 0.08, 0.16, 0...

Development of risk assessment methods for skin sensitization in the absence of toxicological data generated in animals represents a major scientific and technical challenge. The first step in human skin sensitization induction is the transport of sensitizer from the applied dose on the skin surface to the epidermis, where innate immune activation occurs. Building on the previous development of...