Purpose: To formulate and prepare controlled release (CR) matrix tablets of tramadol HCl using Carbopol 974P and 934 polymers as rate-controlling agents. Methods: The tablets were prepared by direct compression method using various drug to polymer (D:P) ratios. Co-excipients, including carboxymethylcellulose, starch and/or hydroxypropyl methylcellulose were also used to modulate the formulation...

Aqueous Zinc Batteries In article number 2301770, Yueliang Gu, Xiaochuan Ren, Daming Zhu, Jianxin Zou, and co-workers elucidate the reaction mechanism of Mn2+ electrolyte additives in aqueous zinc batteries (ZIBs) via operando synchrotron X-ray diffraction, ex situ absorption spectroscopy electrochemical analyses. A reversible Mn2+/MnO2 deposition/dissolution occurred at cathode, which change e...

Article history: Received on: 07/04/2013 Revised on: 29/04/2013 Accepted on: 14/05/2013 Available online: 30/05/2013 In the present study an attempt has been taken to develop Indapamide sustained release matrix tablet using Methocel K15M CR by direct compression method. Various amount of polymer was used in the five proposed formulations (F-1to F-5) for the study of release rate retardant effec...

The purpose of the present work was to design and optimize floating drug delivery systems of acyclovir using psyllium husk and hydroxypropylmethylcellulose K4M as the polymers and sodium bicarbonate as a gas generating agent. The tablets were prepared by wet granulation method. A 3(2) full factorial design was used for optimization of drug release profile. The amount of psyllium husk (X1) and h...

The analysis of the age distributions of star cluster samples of different galaxies has resulted in two very different empirical models for the dissolution of star clusters: the Baltimore model and the Utrecht model. I describe these two models and their differences. The Baltimore model implies that the dissolution of star clusters is mass independent and that about 90% of the clusters are dest...

Occupational exposure to respirable crystalline silica has the ability to cause silicosis. Silica is also suspected of being associated with an increased risk of lung cancer, kidney disease, rheumatoid arthritis, and other diseases. The specific mechanism(s) of pathogenesis for silicosis and these other potential health concerns remains unclear. This investigation measured dissolution rates of ...

Copper has been chosen as an interconnecting material in integrated circuits (IC) because of its low resistivity and high electromigration resistance compared to aluminum and aluminum alloy interconnects. It has been shown recently that the patterning difficulty of copper is resolved by the dual damascene technique, combined with a chemical/mechanical planarization (CMP) process. CMP is becomin...

In this issue of Blood, Zamolodchikov and Strickland examine the association of β-amyloid (Aβ) peptide with fibrin(ogen). These findings shed new light on the relationship between Alzheimer disease and cardiovascular disease, as well as on a novel biochemical mechanism regulating clot stability and dissolution.