The present study describes the development and validation of a dissolution method for carvedilol compression-coated tablets. Dissolution test was performed using a TDT-06T dissolution apparatus. Based on the physiological conditions of the body, 0.1N hydrochloric acid was used as dissolution medium and release was monitored for 2 hours to verify the immediate release pattern of the drug in aci...

We present various aspects of the saturation model which provides good description of inclusive and diffractive DIS at small x. The model uses parton saturation ideas to take into account unitarity requirements. A new scaling predicted by the model in the small x domain is successfully confronted with the data.

xiii CHAPTER ONE INTRODUCTION 1.0 Overview 1 1.1 Problem Statement 3 1.2 Objectives 3 1.3 Proposed Methodology 3 1.4 Thesis Outline 4 CHAPTER TWO LITERATURE REVIEW 2.0 Overview 5 2.1 Mathematical Approach 5

The present work aims to predict drug release from novel site-specific release isoniazid pellets, in USP dissolution test apparatus 3, using the response surface methodology (RSM). Site-specific release isoniazid pellets were prepared by extrusion-spheronization followed by aqueous coating of Acryl-EZE. RSM was employed for designing of the experiment, generation of mathematical models and opti...

The aim of this study was to evaluate the tissue dissolution ability of different irrigating solutions associated or not to ultrasonic agitation. Ninety bovine pulp fragments (n=10 per group) were weighed and then placed individually in Eppendorf test tubes containing the following irrigants: G1- 2.5% sodium hypochlorite (NaOCl); G2- 2.5% NaOCl + ultrasonic agitation (US); G3- 2.5% NaOCl + 0.2%...

Occupational exposure to respirable crystalline silica has the ability to cause silicosis. Silica is also suspected of being associated with an increased risk of lung cancer, kidney disease, rheumatoid arthritis, and other diseases. The specific mechanism(s) of pathogenesis for silicosis and these other potential health concerns remains unclear. This investigation measured dissolution rates of ...

The concentration fluxes in the vicinity of protein crystals growing from its aqueous solution has been investigated using laser based interferometric technique. A Mach-Zehnder interferometer has employed for the experimentation. Lysozyme (Hen-Egg-White) has used as the protein, where sodium chloride (Nacl) is used as the precipitant and Sodium acetate (CH3COONa) as buffer. A test cell with dim...

Metoprolol, a cardioselective β-blocker, is well absorbed in colon after oral administration with mean elimination half life of 3 h with bioavailability 50% due to extensive first pass effect, thus it was aimed to develop its modified release dosage form to reduce dosing frequency. Metoprolol tartrate loaded Eudragit FS microparticles were formulated using solvent evaporation technique by varyi...

Cefixime is a third generation broad spectrum cephalosporin used against many strains of bacteria. It is widely used in oral formulations as suspension and tablets. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for oral use in many clinical conditions along with cefixime. The aim of the current study was to determine the effect of interaction between cefixime and NSAIDs...