introduction: it has been suggested that calculation of differential renal function (drf) using 99mtc-dmsa may lead to overestimation of the function of an obstructed kidney. the aim of this study was to evaluate the effect of diuretic administration on the determination of drf using 99mtc-dmsa scintigraphy in patients with dilated pelvis. methods: thirty three patients, aged from 2 months to 6...

A known side-activity of the oral potassium-sparing diuretic drug amiloride is inhibition of the enzyme urokinase-type plasminogen activator (uPA, K(i)=7 μM), a promising anticancer target. Several studies have demonstrated significant antitumor/metastasis properties for amiloride in animal cancer models and it would appear that these arise, at least in part, through inhibition of uPA. Selectiv...

The clinical and neuroendocrine response to diuretic treatment was assessed at rest and on exercise in 12 patients with heart failure. Before treatment all patients were limited by breathlessness on exercise; one was oedematous. Plasma renin activity and aldosterone were normal but plasma noradrenaline was raised both at rest and on exercise. After one month's treatment with frusemide (40 mg) a...

Vediyuppu cheyaneer has been widely used in Siddha system of medicine for various diseases. The liquid form of Vediyuppu cheyaneer showed a significant inhibitory effect when screened at 500 mg/kg, for the invivo antiurolithiasis activity on ethylene glycol induced hyperoxaluria rats. The standard frusemide (20 mg/kg) and cystone (750 mg /kg) were used as comparison for diuretic and antiurolith...