Severe coronary artery bypass graft disease occurs at a rate of approximately 16%-31% within the first year of surgery. Clinical and laboratory variables, including postoperative lipid profiles closest to the 1-year follow-up, lipoprotein(a) levels, and homocysteine levels, were assessed as predictors of early (< or = 1 year) symptomatic coronary artery bypass graft disease. Of 77 living consec...

Annotation. Defeat of the respiratory system is a common phenomenon in today's conditions. Elevated levels homocysteine (Hz) are one predictors bronchopulmonary pathology. In recent years, there has been an association between its concentration blood plasma and risk developing COPD, bronchial asthma, lung cancer. The pathogenesis damage hyperhomocysteinemia (GHz) still being studied, but it kno...

Proven effective alternative and adjunctive therapies for lipid lowering could be beneficial for patients with hyperlipidemia. We evaluated a 90% soluble fiber for its ability to alter lipid, lipoprotein, and homocysteine levels in the setting of coadministered folate and B vitamins. Patients (n = 119) were randomized to either the fiber and vitamin combination, or placebo. Fasting lipid, gluco...

BACKGROUND High blood lead (Pb) and hyperhomocysteinemia have been found to be associated with cardiovascular disease (CVD). Mean blood Pb and mean plasma homocysteine levels have been reported to be high in Pakistani population. The objective of the present study was to assess the relationship of blood Pb to the risk of hyperhomocysteinemia in a low income urban population of Karachi, Pakistan...

OBJECTIVE To assess biochemical, anthropometric, and dietary variables considered risk factors for coronary artery disease. METHODS Using anthropometrics, dietary allowance, and blood biochemistry, we assessed 84 patients [54 males (mean age of 55+/- 8 years) and 30 females (mean age of 57+/-7 years)], who had severe (>/= 70% coronary artery obstruction) and nonsevere forms of coronary artery...

A four-day-old boy with a positive result in newborn-screening testing was referred to the hospital for further evaluation. He was the product of a 39-week gestation and appeared well at birth. His laboratory results included the following plasma findings: ammonia, 109 g/dL (reference interval, 20 – 65 g/dL); citrulline, 169 mol/L (reference interval, 2–50 mol/L); and leucine, 278 mol/L (refere...

Previous communications from this laboratory have presented evidence that the unsymmetrical thio ether, ZZ-S-(@-amino-~-carboxyethyl)homocysteine (cystathionine),’ may serve in lieu of cystine for the growth of rats (2) and that an enzyme is present in the liver capable of cleaving the thio ether to yield cysteine (3). Brand, in his original suggestion (4) regarding this thio ether as an interm...

OBJECTIVE The widely prescribed anticonvulsants phenytoin and carbamazepine are potent inducers of cytochrome P450 enzymes, which are involved in cholesterol synthesis. We sought to determine whether these drugs have an effect on cholesterol and other serological markers of vascular risk. METHODS We recruited 34 epilepsy patients taking carbamazepine or phenytoin in monotherapy whose physicia...