In vitro studies have suggested that dopamine D1- and D2-like receptors interact to inhibit renal sodium transport. We used Z-1046, a dopamine receptor agonist with the rank-order potency D3 ≥ D4 > D2 > D5 > D1, to test the hypothesis that D1- and D2-like receptors interact to inhibit renal sodium transport in vivo in anesthetized rats. Increasing doses of Z-1046, administered via the right ren...

1. We have measured regional cerebral blood flow (rCBF) and motor function before and after the subcutaneous (s.c.) injection of apomorphine in parkinsonian patients deprived of their usual treatment for at least 48 h. 2. Nineteen patients, pretreated with domperidone (20 mg three times daily for 48 h), received a mean dose of 5.8 mg s.c. apomorphine. All patients switched 'on'. The mean motor ...

A liquid chromatography coupled with mass spectrometry method was developed and validated to determine omeprazole and domperidone simultaneously in dog plasma. Chromatographic separation was performed on a Narrow Bore C(18) column using methanol-10 mM ammonium acetate (68:32, v/v) as the mobile phase at the flow rate of 0.2 mL/min. The chromatographic separation was achieved in less than 7 min....

Drug release from polymeric matrix systems is the rate-limiting step for drug bioavailability and is determined by drug solubility; most drugs show pH-dependent solubility. Polymeric matrices remain in the gastrointestinal tract for a longer period of time and are exposed to environments of varying pH, which can adversely affect drug release. In the present study, the pH-independent drug releas...

A simple and rapid method has been developed for the quantification of Domperidone (DMP) and Ranitidine (RAN) through FT-IR in combined dosage form. The method involves the measurement of peaks of amine (-NH) at 1620 cm -1 (RAN) and carbonyl group (C=O) at 1717 cm -1 (DMP). The method was validated for pharmaceuticals in tablet form and found to be precise with high recovery levels (>99%).

“Ovaprim-C” manufactured by a Canada-based company, M/s Syndel laboratories, is in use world over today for induced spawning of fishes. Ovaprim-C contains 20 μg of Salmon gonadotropin releasing hormone (GnRH) and 10 mg of domperidone ml. The high cost and viscosity of Ovaprim proved a prohibitive factor. Another synthetic hormone “Ovatide” has been manufactured by a Mumbay based M/s Hemmo Pharm...

BACKGROUND AND PURPOSE Inhibition of HERG channels prolongs the ventricular action potential and the QT interval with the risk of torsade de pointes arrhythmias and sudden cardiac death. Many drugs induce greater inhibition of HERG channels when the cell membrane is depolarized frequently. The dependence of inhibition on the pulsing rate may yield different IC(50) values at different frequencie...

In the present study, respiratory drives to chemical stimuli and peripheral chemosensitivity were evaluated in patients with obstructive sleep apnoea (OSAS). The effects of oral administration of domperidone, a selective dopamine D2-receptor antagonist, were also examined, to study the respiratory effects of endogenous dopamine on peripheral chemoreceptors. Sixteen patients with OSAS and nine n...

AIM to evaluate the efficacy of combination of PPI with prokinetic drug compared to PPI mono therapy in GERD patients with high frequency scale for the symptoms of GERD (FSSG) score. METHODS sixty dyspeptic patients having heartburn and/or regurgitation were recruited during the period of July 2010-April 2011 in this double blind clinical trial. By randomization, they were divided into two gr...