AIM Catecholamines regulate functions of the nervous, neuroendocrine and immune systems. Dopamine may modulate the activity of keratinocytes, which play a role in secreting cytokines and chemokines. The aim of this study was to evaluate the effect of dopaminergic agonists on the production of IL-6 and IL-8 by a non-tumoral human keratinocyte cell line (HaCaT). METHODS Cells were stimulated wi...

It is suggested that the antidopaminergic effects of neuroleptics are not directly responsible for the antipsychotic effect but, rather, that the antipsychotic effect is related to secondary changes in the efficacy of transmission at corticostriatal excitatory synapses. Arguments are presented in support of the following: (1) acute dopaminergic antagonism produces a relatively nonspecific sedat...

Introduction Three generations of antipsychotics, all which are based on the dopaminergic hypothesis schizophrenia, available for clinical use. Still, more than 66% patients diagnosed with schizophrenia spectrum disorders (SSD) could not achieve remission. Also, glutamatergic is supported by translational models this disease, even if antipsychotics derived from conceptual framework yet market. ...

Synergisms between pharmacological agents and endogenous neurotransmitters are familiar and frequent. The present review describes the experimental evidence for interactions between neuropharmacological compounds and the classes of weak magnetic fields that might be encountered in our daily environments. Whereas drugs mediate their effects through specific spatial (molecular) structures, magnet...

Sir: The pathophysiology of Hunting-ton's disease remains unknown, but recent research has pointed out defects of several neurotransmitter systems in the corpus striatum of such patients. Both cholinergic' and GABA-ergic2 transmission are thought to be diminished, and substance P-containing neurons may be reduced,3 indicating a complex patho-physiology. Dopaminergic transmission, on the other h...

Substance abuse and addiction are the most costly of all the neuropsychiatric disorders. In the last decades, much progress has been achieved in understanding the effects of the drugs of abuse in the brain. However, efficient treatments that prevent relapse have not been developed. Drug addiction is now considered a brain disease, because the abuse of drugs affects several brain functions. Neur...

properties at high blood concentrations. MacLeod and Lamberts3 have shown the dopamine agonist effects of high concentrations of haloperidol and pimozide on prolactin release. Seeman4 has shown that very high concentrations of some antipsychotic drugs may enhance presynaptic release of neurotransmitters, including dopamine. Altematively, at high concentrations of antipsychotic drugs maximal dop...