Hypothetic structures of H5T/TNF-carb (a) and TPh-3A/TNF-carb (b).

Background: Laryngoscopy is the most painful noxious stimulus during anesthesia and surgery. Dexmedetomidine increasingly used as a sedative in surgeries involving microlaryngoscopy. Objectives: This study aimed to evaluate effect of dexmedetomidine combination fentanyl midazolam on mitigating stress response patients scheduled for Methods: randomized, double-blind clinical trial enrolled 60 (2...

The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs. Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi-Goutières syndrome (AGS) or dystonia arising from striatal neurodegeneration. Adar1 mutant mouse embryos show aberrant interferon induction and die by embryonic day E12.5. We demonstrate that Adar1 embryonic lethality is res...