Attempts to improve formulation of topical products are a continuing process and the development of microandnanovesicular systems as well as polymeric microparticles has led to marketing of topical drugs and cosmetics usingthese technologies. Encapsulation of some well-known contact allergens in ethanolic liposomes have been reportedto enhance allergenicity compared with the all...

The First International Research Capacity-Building Program for Nurses to Study the Drug Phenomenon in the Americas is a result of a partnership between the Inter-American Drug Abuse Control Commission (CICAD) of the Organization of American States (OAS) and the Faculty of Nursing in the University of Alberta, with financial support from the Government of Canada. The program was divided into two...

Polypropylenimine (PPI) dendrimers have been widely used as effective delivery vehicles for drugs and nucleic acids during the past decade. However, biomedical applications of PPI dendrimers were limited because of their serious cytotoxicity and low drug loading capacity. In the present study, acetylated PPI dendrimers with different degrees of acetylation ranging from 14.2% to 94.3% were synth...

Several large studies in Europe and the USA revealed that approximately 10% of all newly diagnosed patients harbour HIV-1 variants with at least one major resistance-associated mutation. In this review we discuss the underlying mechanisms that drive the evolution of drug-resistant viruses after transmission to the new host. In a comprehensive literature search 12 papers describing the evolution...

Co-delivery approach has been recommended to reduce the amount of each drug and to achieve the synergistic effect for cancer treatment. CUR and SF have antitumor effects, but their application is limited because of their low water solubility and poor oral bioavailability. To improve the bioavailability and solubility of SF and CUR, we performed an innovative co-delivery of SF and CUR with magne...

Introduction: Toxic effects of pesticides are commonly associated with reactive oxygen species damage and pentoxifylline a phosphodiesterase inhibitor is a drug well known for antioxidant properties. The purpose of this study was to evaluate the oxidative damages following a subacute exposure to malathion, an organophosphorus insecticide and pentoxifylline's ability to counteract these effect...

Objective: The role of herbs against the free radicals have been put forth recently in combating many diseases. The aim of this study was to elucidate the in vitro capacity and in vivo antioxidant properties of sedimental extract of Tinospora cordifolia (SETc). Materials and Methods: SETcwas subjected to in vitro chemical analysis such as 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide, hydr...