microparticles offer various significant advantages as drug delivery systems, including: (i) an effective protection of the encapsulated active agent against (e.g. enzymatic) degradation, (ii) the possibility to accurately control the release rate of the incorporated drug over periods of hours to months, (iii) an easy administration (compared to alternative parenteral controlled release dosage ...

prohibitins are chaperone proteins highly conserved among eukaryotes. many different functions have been attributed to prohibitins depending on their tissue expression and sub-cellular localization. prohibitins play a major role in mitochondrial physiology, regulating the stability and the processing of both respiratory chain complex subunits and opa1, a mitochondrial fusion regulating protein....

background: the reporting of adverse drug reactions (adrs) by nurses in hospitals is very important.aims: this study was aimed at investigating the impact of an educational intervention to improve adr reporting and whethertrained nurses had better knowledge, attitude, and practice toward adr reporting. materials and methods: a total of 300 nurses in a tertiary care teaching hospital in tehran, ...

conclusions in this study, like previous researches, e. coli was the most common pathogen. our results suggested a high rate of antibiotic resistance to common antibiotics for treatment of uti. because of the high resistance to cephalexin, cefotaxime and co-trimoxazole, their use is not recommended for treatment of utis. imipenem and vancomycin were the most active drugs against e. coli and sta...

background: substance abuse is one of the most complicated social problems. understanding socio-demographic characteristics of those who abuse substances could help deal with this problem more efficiently. the main objective of this study was to determine socio-demographic characteristics associated with alcohol drinking, cigarettes smoking and drug abuse among a sample of male medical universi...

comparative study on toxoplasma serology among hiv positive and hiv negative illicit drug users in ahvaz, iran

the objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (dds) for metoprolol tartarate (mt) as tablet and capsule. pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery ...

background staphylococcus aureus is a significant pathogen that can colonize the nares of different animals, causing a wide range of infections in various hosts. objectives we intended to determine the prevalence of s. aureus in the nasal cavity of healthy ruminants and also to investigate the presence of antibiotic resistance genes. materials and methods in the present study, healthy cattle (n...

conclusions induction of coccoid form of p. aeruginosa may be one of the important reasons for antibiotic treatment failure; therefore, prescribed dose of antibiotics should be carefully managed to prevent increasing antibiotic resistance and coccoid bacteria induction. results all used antibiotics at sub mic concentration had capability to induce coccoid bacteria. the highest rate of induced c...