INTRODUCTION The release of the drug substance from a solid dosage form has a major impact on its rate and extent of absorption. In certain instances, as is the case with modified-release formulations, the rate-limiting step in the appearance of the drug in the systemic circulation is its release from the formulation. In the vast majority of cases, in vitro dissolution of an immediate-release p...

Cancer is a disease of biological and cell cycle processes, driven by dosage of the limited set of drugs, resistance, mutations, and side effects. The identification of such limited set of drugs and their targets, pathways, and effects based on large scale multi-omics, multidimensional datasets is one of key challenging tasks in data-driven cancer genomics. This paper demonstrates the use of pu...

The objective of this study is to investigate the quality of drug prescriptions in nine health centres of three districts in rural Burkina Faso. 313 outpatient consultations were studied by methods of guided observation. Additionally interviews were held with the health care workers involved in the study. A total of 793 drugs prescribed by 15 health care workers during the observation period an...

INTRODUCTION Absorption of drugs through the gastrointestinal tract poses a variety of limitations, making the in vivo performance of drug delivery systems uncertain. Following on from recent advances, in a time of increased consideration of floating drug delivery systems, it is as important as ever to continue the progress by studying different aspects of these systems. Moreover, it seems impe...

A new, rapid, economical and isocratic reverse phase high performance liquid chromatography (RP-HPLC) method was developed for the determination of eptifibatide acetate, a small synthetic antiplatelet peptide, in bulk drug substance and pharmaceutical dosage forms. The developed method was validated as per of ICH guidelines. The chromatographic separation was achieved isocratically on C18 colum...

Pharmacokinetic studies have made many significant contributions to rational therapeutics in children. Pharmacokinetic data have helped distinguish between differences in drug disposition and drug sensitivity in children as compared to adults and led to the establishment of age-specific dosage guidelines. Factors influencing the observed differences between drug disposition in children and adul...