Sepsis is one of the leading causes mortality in intensive care units. Its increases, 
 especially with high number comorbidities and immunosuppression. Hemophagocytic syndrome an uncontrolled cytokine storm that develops course increased inflammatory conditions such as sepsis. The clinical picture very wide; because nonspecific symptoms. For this reason; to diagnose hemophagocytic syndrom...

This case report describes two severe antiretroviral drug adverse reactions that occurred in the same patient. A 55-year-old HIV-positive African woman received a single epidural triamcinolone injection for pain relief of postherpetic neuralgia. Forty-one days later, she developed severe iatrogenic Cushing's syndrome due to the drug-drug interaction between triamcinolone and her boosted proteas...

Collections of individual case safety reports are the main resource for early discovery of unknown adverse reactions to drugs once they have been introduced to the general public. The data sets involved are complex and based on voluntary submission of reports, but contain pieces of very important information. The aim of this thesis is to propose computationally feasible statistical methods for ...

Drug-induced cutaneous rashes, whether confined to the skin or part of a systemic disease, are characterised by a spectrum of inflammatory disease patterns that include perivascular dermatitis, nodular and diffuse dermatitis, vesiculobullous lesions, pustular eruptions, sclerodermoid reactions, vasculitis, folliculitis/perifolliculitis and panniculitis. While a single drug can elicit a range of...

Background. Drug allergies are an important part of the patient record. Unlike active problems, medications, and laboratory values, allergies are seldom removed from the record and are not subject to rapid change.' The common method of listing drug allergies in the patient record lacks important information about the allergy or reaction: What reaction occurred? How certain is it that the reacti...