the present investigation deals with the development of controlled release tablets of salbutamol sulphate using graft copolymers (st-g-pmma and ast-g-pmma) of starch and acetylated starch. drug excipient compatibility was spectroscopically analyzed via ft-ir, which confirmed no interaction between drug and other excipients. formulations were evaluated for physical characteristics like hardness,...

modification of the mechanical properties of silicone rubber were considered for drug delivery systems by using high-energy electron beam (e-beam). in this research work, two different medical grades of silicone rubbers were used to prepare matrices containing 10wt% progesterone with 2 mm thickness and irradiated with e-beam at dose range of 25 up to 200 kgy. then, the mechanical properties as ...

patient noncompliance to current tuberculosis (tb) therapy owing to multidrug administration daily leads to treatment failure and emergence of multidrug resistant and extensively drug resistant tb. to avoid the daily dosing, application of nanotechnology is the only viable solution by virtue of sustained release of drugs. other potential advantages of the system include the possibility of selec...

In the present study, Floating Drug Delivery Beads (FDDS) were prepared with sodium alginate/ starch blend as a matrix, sodium hydrogen carbonate as a pore forming agent, methyl cellulose as a binder and barium chloride solution as a hardening agent. In order to prepare the beads with different porosity and morphology the ratio between pore forming agent to polymer blend and ratio of the co...

objective(s): a box-behnken design was used for evaluation of eudragit coated diclofenac pellets. the purpose of this work was to optimize diclofenac pellets to improve the physicochemical properties using experimental design. materials and methods: diclofenac was loaded onto the non-pareil beads using conventional coating pan. film coating of pellets was done at the same pan. the effect of pla...

Purpose: Enalapril maleate (EPM), was used for hypertension and congestive heart failure. In this way, an innovative delivery system with mPEG–PCL was synthesized and the release profile of the EPM from the drug-loaded polymersomes was evaluated. Methods: Di-block methoxy)-poly (ethylene glycol) - Poly (caprolactone) (mPEG-PCL) copolymers were synthesized and used to prepare of polymersom...

the effect of different kinds of surfactants in various concentrations incorporated in an inert matrix, on the release of procainamide hydrochloride, as a cationic model compound, was investigated in this study. sodium lauryl sulfate and sodium stearate as anionic surfactants, cetyl pyridinium chloride and cetyltrimethyl ammonium bromide as cationic and span 60 and tween 80 as non-ionic surfact...

Because of their bioadaptability and multi-functional characteristics, cyclodextrins (CDs) are capable of alleviating the undesirable properties of drug molecules in various routes of administration through the formation of inclusion complexes. This article outlines the current application of natural and chemically modified CDs in the design of advanced dosage forms. In an oral drug delivery sy...

The aim of this study was to develop an extended-release tablet formulation using a new in situ cross-linking method. The effects of polyvalent cations on theophylline release from tablets made with the polyanionic polymers sodium alginate and sodium carboxymethylcellulose, were investigated. Different miliequivalents of the di and tri-valent cation, Ca2+ and Al3+, were added to tablet form...