Residues of Veterinary drugs are one of the major problems for food contamination. Veterinary drugs residues usually accumulate in the liver or kidney rather than other tissues. Fenbendazole is an anthelmintic frequently used in farm animals to treat parasitic infestations in pig [1]. The most likely reasons for Fenbendazole residues may result from human management, such as improper usage, inc...

Protein kinases are promising drug targets for Leishmaniasis. We have evaluated the phosphorylation potential of protein kinases in different species and strains of Leishmania. Phosphorylation potential of serine, threonine and tyrosine residues of kinases in Leishmania parasite were studied. The results indicate that some species specific residues of serine, threonine and tyrosine have a phosp...

Kv1.5 channel blockers prolong atrial action potentials and may prevent atrial flutter or fibrillation without affecting ventricular repolarization. Here we characterize the mechanisms of action of 2'-{[2-(4-methoxy-phenyl)-acetylamino]-methyl}-biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)-amide (AVE0118) on Kv1.5 channels heterologously expressed in Xenopus laevis oocytes. Whole cell curre...

Membrane-located drug transporters are important components in the multidrug resistance of microbial cells and human tissues. In fungi, clinically important resistance to antifungal drugs most often results from the over-expression of efflux pump proteins in the plasma membrane of the resistant cell. This review describes studies of the ATP binding cassette (ABC) family of membrane efflux pumps...

Beginning in the 1980s, concerns about the deleterious effects of synthetic pesticides have driven a significant Southeast Asian research and development effort directed towards alternative pest control strategies, including the use of microbial control agents. Despite this effort, use of microbial control agents has grown slowly in the region. This is the result of an interplay between interna...