نتایج جستجو برای: drug safety evaluation
تعداد نتایج: 1576394 فیلتر نتایج به سال:
Prescribers seek to provide their patients with access to the latest innovations in medicine to maximize their health status. When a new drug comes to market, it often has not been as widely tested as other available therapies, and its effectiveness and safety cannot be fully evaluated. To address this problem, physicians can use the STEPS (Safety, Tolerability, Effectiveness, Price, and Simpli...
In October 2008, in a public forum organized by the Cardiac Safety Research Consortium and the Health and Environmental Sciences Institute, leaders from government, the pharmaceutical industry, and academia convened in Bethesda, MD, to discuss current challenges in evaluation of short- and long-term cardiovascular safety during drug development. The current paradigm for premarket evaluation of ...
Evaluation of outpatient computerized physician medication order entry systems: a systematic review.
This paper provides a systematic literature review of CPOE evaluation studies in the outpatient setting on: safety; cost and efficiency; adherence to guideline; alerts; time; and satisfaction, usage, and usability. Thirty articles with original data (randomized clinical trial, non-randomized clinical trial, or observational study designs) met the inclusion criteria. Only four studies assessed t...
Applications and limitations of interspecies scaling and in vitro extrapolation in pharmacokinetics.
The search for new drugs is an extremely time-consuming and costly endeavor. Much of the time and cost are expended on generating data that support the efficacy and safety profiles of the drug. Because of ethical constraints, relevant pharmacological and toxicological assessments must be made in laboratory animals and in in vitro systems before human testing can begin. In support of the efficac...
To capitalize on the vast potential of patient genetic information to aid in assuring drug safety, a substantial effort is needed in both the training of healthcare professionals and the operational enablement of clinical environments. Our research aims to satisfy these needs through the development of a drug safety assurance information system (GeneScription) based on clinical genotyping that ...
the interest of dental research in metal-free restorations has been rising in the last 20 years following the introduction of innovative all-ceramic materials in the daily practice. in particular, high-strength ceramics and related cad/cam techniques have widely increased the clinical indications of metal-free restorations, showing more favorable mechanical characteristics compared to the early...
OBJECTIVE To improve the methods for long-term assessment of drug-associated side effects and advance knowledge of the safety profile of psychotropic medications in children and adolescents. METHOD A multidisciplinary, interactive workshop was hosted by the National Institute of Mental Health (NIMH) and the Research Units on Pediatric Psychopharmacology network. Participants were experts in c...
To meet state and OSHA requirements for dealing with and reporting workplace violence, a growing number of hospitals, the author reports, are turning to baseline workplace violence assessments which survey employees in different roles, combined with a threat analysis and an analysis of existing controls and historical incidents that can be reviewed and tracked over time to show improvement or d...
1. ABSTRACT This paper will focus on changes to the implementation of road safety inspections in Ireland following the requirement, under EU Directive 2008/96/EC on Road Infrastructure Safety Management (2008), for the establishment of periodic road safety inspections (RSI) of existing roads, along with safety impact assessments, high accident concentration ranking and road safety audits (RSA)....
Pharmaceutical chemistry is used to the development and assessment of therapeutic compounds. And the Pharmaceutical chemistry encompasses drug design, drug synthesis, and the evaluation of drug efficacy (how effective it is in treating a condition) and drug safety. Drug discovery is the core of pharmaceutical chemistry. The drug discovery process includes all the stages of drug development, fro...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید