Coupling an infrared (IR) camera to a freeze dryer for on-line monitoring of freeze-drying cycles is described for the first time. Normally, product temperature is measured using a few invasive Pt-100 probes, resulting in poor spatial resolution. To overcome this, an IR camera was placed on a process-scale freeze dryer. Imaging took place every 120 s through a Germanium window comprising 30,000...

sion/spheronization affects the properties of the resulting pellets. Pharmaceutical scientists originally directed their focus to extrusion, spheronization and drying which can be seen from the literature. Only a few authors reported investigations concerning the impact of the granulation step. Baert et al. investigated ternary mixtures of microcrystalline cellulose (MCC), a drug substitute and...

In recent years amorphous solid dispersions (ASD) has gained a tremendous response for improving the solubility of poorly water-soluble drug substances. Despite stability challenges, various ASD commercial products have been successfully launched into market over last two decades. Among manufacturing approaches, hot melt extrusion (HME) and spray drying techniques attracted industries attributi...

BACKGROUND Drying of nectarine slices was performed to determine the thermal and physical properties in order to reduce product deterioration due to chemical reactions, facilitate storage and lower transportation costs. Because nectarine slices are sensitive to heat with long drying period, the selection of a suitable drying approach is a challenging task. Infrared-vacuum drying can be used as ...

Under optimal freeze-drying conditions, solutions exhibit a cake-like porous structure. However, if the solution temperature is higher than the glass transition temperature of the maximally freeze-concentrated phase (Tg') during drying phase, the glassy matrix undergoes viscous flow, resulting in cake collapse. The purpose of the present study was to investigate the effect of cake collapse on t...

Cereal Chem. 80(1):30–34 Flours and starches from rough rice dried using different treatment combinations of air temperature (T) and relative humidity (RH) were studied to better understand the effect of drying regime on rice functionality. Rough rice from cultivars Bengal and Cypress were dried to a moisture content of 12% by three drying regimes: low temperature (T 20°C, RH 50%), medium tempe...

A five level four factors central composite rotatable design under response surface methodology was used to optimize process conditions of the foam mat drying process i.e. egg albumen (0%-12%), methyl cellulose (0.1%-0.5%), drying bed thickness (3-7 mm) and drying temperature (55-75°C) to develop grape bar with final moisture content of 14%±1% (dry-base). Contour and response graphs were genera...

in this research the drying of four kinds of vegetables was investigated in a vacuum dryer. the effect of temperature on drying rate of samples at various temperatures (30, 35 and 45 °c) was studied. six thin-layer drying models were fitted to drying data and suitable model was selected from them. then effective moisture diffusivity and activation energy of samples were calculated. the diffusio...