Absolute protein quantification using mass spectrometry (MS)-based proteomics delivers protein concentrations or copy numbers per cell. Existing methodologies typically require a combination of isotope-labeled spike-in references, cell counting, and protein concentration measurements. Here we present a novel method that delivers similar quantitative results directly from deep eukaryotic proteom...

Background: Breast cancer is a common disease in radiation oncology. We evaluated the radiation dose received by breast cancer patients, an often-neglected concern. Materials and Methods: The total effective radiation dose in 101 breast cancer patients was calculated by summing the effective doses of individual diagnostic imaging tests from the first hospital visit to the initiation of radiothe...

  The advent of dual-modality PET/CT imaging has revolutionized the practice of clinical oncology, cardiology and neurology by improving lesions localization and the possibility of accurate quantitative analysis. In addition, the use of CT images for CT-based attenuation correction (CTAC) allows to decrease the overall scanning time and to create a noise-free attenuat...

Since the early days of geochemical isotope ratio mass spectrometry there has always been the problem of cross contamination, i.e. the contamination of the sample gas with traces of reference gas (and vice versa) in a dual inlet system and the analyzer itself. This was attributable to valve leakages and could be corrected for. In modern leak-free machines this problem still influences the measu...

Radiolabeled liposomes have been employed as diagnostic tools to monitor in vivo distribution of liposomes in real-time, which helps in optimizing the therapeutic efficacy of the liposomal drug delivery. This work utilizes the platform of [111In]-Liposome as a drug delivery vehicle, encapsulating a novel 18F-labeled carboplatin drug derivative ([18F]-FCP) as a dual-molecular imaging tool as bot...

An Affibody based dual imaging probe (PET and optical imaging) has been successfully developed. Dendrimer PAMAM G0 was used as a platform to assemble an NIRF dye, a metal chelator, and Affibody for dual modality imaging of ovarian cancer. Excellent tumor imaging quality was achieved in both modalities in the living tumor mice models.

Introduction Conclusions References

In previous series of contributions, Inverse Least Squares (ILS) Numerical Optimization, 3D/4D Interior Graphical Optimization software and algorithms-programming were presented. The BCS theory Isotope Effect applications on superconductors TC dual/multiobjective optimization was the main subject. This contribution deals with Molecular Model for High Temperature Superconductors (HTSCs), in prim...