Abnormal uterine bleeding is any bleeding from the uterus other than normal monthly period. Having extremely heavy bleeding during period can also be considered abnormal uterine bleeding. Dysfunctional uterine bleeding (DUB) is heavy or irregular menstrual bleeding that is not caused by an underlying anatomical abnormality, such as a fibroid, lesion, or tumor. DUB is the most common type of abn...

A panel of [Au(III)(C^N)(R2NCS2)](+) (HC^N = 2-phenylpyridine) complexes displayed significant deubiquitinases (DUBs) inhibitory activity; one of these complexes showed selective in vitro cytotoxicity towards breast cancer cells correlated to high cellular uptake of gold, and induced cell-cycle arrest, apoptosis, and anti-angiogenic property that could be related to DUB inhibitory activity.

Abnormal Uterine Bleeding (AUB) is a common cause for concern among adolescents and their families, as well as a frequent cause of visits to the Emergency Department and/or health care provider. (1) While there are many etiologies of AUB, the one most likely among otherwise healthy adolescents is Dysfunctional Uterine Bleeding (DUB).

The cylindromatous gene Cyld encodes a deubiquitylase (DUB), which regulates NF-jB activation. CYLD deficiency results in faulty innate and adaptive immune systems in mice, the basis for which remains incompletely understood. In this issue of The EMBO Journal, Sun and colleagues report that CYLD-deficient mice develop the innatelike lymphocyte called natural killer T (NKT) cells but lose them t...

Understanding the factors, which control ErbB2 and EGF receptor (EGFR) status in cells is likely to inform future therapeutic approaches directed at these potent oncogenes. ErbB2 is resistant to stimulus-induced degradation and high levels of over-expression can inhibit EGF receptor down-regulation. We now show that for HeLa cells expressing similar numbers of EGFR and ErbB2, EGFR down-regulati...

Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-secretase, giving rise to a soluble, transcriptionally active molecule. The Notch1 receptor was proposed to be monoubiquitinated before its gamma-secretase cleavage; the targeted lysine has be...