BACKGROUND In view of the conflicting opinions published, a meta-analysis was undertaken on epidemiological studies in order to assess any association between Dupuytren's contracture and work exposure. METHODS Using the key words: "occupational disease", "work" and "Dupuytren contracture" without limitation on language or year of publication, epidemiological studies were selected from four da...

BACKGROUND In Dupuytren's disease (DD), limited fasciectomy is the mainstay of surgical therapy in patients at risk of contractures and disease recurrences. New minimally invasive treatments such as injection of collagenase clostridium histolyticum have evolved as a common tool for the preliminary treatment of Dupuytren's contractures. However, recurrences and their therapy remain controversial...

PURPOSE To document orofacial rehabilitation and outcomes after full thickness orofacial burn. METHODS Participants included 12 consecutive patients presenting with full thickness orofacial burns. A group of 120 age-matched healthy participants was recruited for normative comparison. Non-surgical exercise was initiated within 48 h of admission and continued until wounds had healed, circumoral...

Dupuytren's disease is a fibroproliferative condition involving the superficial palmar fascia, leading to a progressive and irreversible flexion of the fingers. In literature, there are different opinions regarding the phenobarbital, a common antiepileptic drug, and its effective role in the genesis and development of Dupuytren's disease. In this retrospective investigation the association betw...

OBJECTIVE To study the clinical profile and mutation spectrum of Hunter syndrome. METHODS Evaluation of 18 cases of Hunter syndrome from 17 families was done. Mutation analysis of Iduronate sulfatase (IDS) gene was done in 9 families, and mothers of four affected children with no family history. RESULTS Joint contracture, hepatomegaly and radiological changes were present in all children. 6...

PURPOSE Collagenase has been investigated in phase II and phase III clinical trials for the treatment of Dupuytren's disease. The purpose of this study is to report 8-year follow-up results in a subset of patients who had collagenase injection for the treatment of Dupuytren's contracture. METHODS Twenty-three patients who participated in the phase II clinical trial of injectable collagenase w...

louis hubert farabeuf was born in bannost (sein-et-marne) on may 6th 1841 and died in beton-bazoche (aisne) in august 1910. he was professor and director of the anatomical department of the faculty of medicine in paris until 1878. in 1879, he founded the school of practical studies in paris, which contributed to anatomical studies. farabeuf designed many surgical procedures. his manual of opera...

OBJETIVE: Many physical or medical therapeutic approaches, systemic or local, have been suggested for treatment of Peyronie's disease. These approaches claim a discrete percentage of success in terms of clinical stabilization or improvement. The aim of our work was to evaluate the " natural history " of this disease. METHOD: 110 patients affected by Peyronie's disease have been observed for at ...