The buccal region of oral cavity is an attractive site for administration of drug of choice. Buccal route is an excellent for systemic delivery of drug providing great bioavailability. A significant reduction in dose and dosing frequency can be achieved, thereby reducing dose dependent side effects, patient compliance and prolonging duration of action.Buccal dosage form increase bioavailability...

CONTEXT Thiomers could prove to be suitable mucoadhesives for fabrication of ocular inserts. OBJECTIVE The study intends to explore the application of thiolated sodium alginate (TSA) to the preparation of bilayered ocular inserts of gatifloxacin. METHODS Cysteine moieties were grafted onto sodium alginate (SA) and the resultant thiomer was characterized for relevant physicochemical properti...

The purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive propranolol hydrochloride microspheres for its potential use in the treatment of hypertension, myocardial infraction and cardiac arrhythmias. Propranolol hydrochloride mucoadhesive microspheres, containing carbopol-934P as mucoadhesive polymer and ethyl cellulose as carrier ...

The design of grating-based instruments to handle and condition coherent ultrafast pulses in the extreme-ultraviolet is discussed. The main application of such instruments is the monochromatization of high-order laser harmonics and free-electron-laser pulses in the femtosecond time scale. Broad-band monochromators require the use of diffraction gratings at grazing incidence. A grating can be us...

Buccal delivery involves the administration of the desired drug through the buccal mucosal membrane lining of the oral cavity.The objective of this article is to review buccal drug delivery by discussing the structure and environment of the oral mucosa and highlighting the mechanisms of drug permeation and methodology in evaluating buccal formulations. This review also highlights a brief descri...

abstract background: the readiness of mothers to take care for infants at discharge is a critical issue. poor readiness of mothers in taking care of premature infants at the time of discharge is associated with potential adverse consequences. this study examined the effect of implementing mothers’ empowerment program on the weight gain and duration of hospitalization in premature infants. mater...

the aim of the present study was to prepare and evaluate an osmotically controlled mucoadhesive cup-core (ocmc) containing aceclofenac. a special technique was used while preparing an ocmc. stability of ocmc was determined in natural human saliva, and it was found that both ph and device are stable in human saliva. ocmc was evaluated by weight uniformity, thickness, hardness, friability, swelli...

OBJECTIVE Betahistine dihydrochloride (BH.2HCl), an anti-vertigo histamine analog used in the treatment of Ménière's disease, undergoes extensive first-pass metabolism and suffers from short biological half-life. The aim of the present work was to develop and estimate controlled release mucoadhesive buccal tablets of BH.2HCl with a unidirectional drug flow to overcome this encumbrance. METHOD...