Molecules are dynamic entities, and understanding intra- inter-molecular reactions changes in conformation is one of the most fascinating, important complex subjects NMR. Conformational chemical result observed spins exchanging between different magnetic environments, sensitivity NMR spectra to such processes has been recognised since earliest days field. Careful analysis spectra, acquired usin...

Imaging with spoiled, balanced or nonbalanced gradient echo (GRE) refers to a class of fast imaging sequences that use a dynamic equilibrium or steady state signal for imaging. As originally introduced in 1958 by Carr (1) for NMR spectroscopy, a dynamic equilibrium or steadystate can be established by a train of radio-frequency (RF) excitation pulses interleaved by periods of ‘free precession’,...

The structure and dynamic behaviour of monomeric lead(ii) dithiolate Pb(SCH(2)CH(2)NMe(2))(2) are studied by multi-nuclear NMR, IR and Raman spectroscopy in solution, as well as variable-temperature Raman spectroscopy and X-ray diffraction analysis in the solid-state, revealing an unusual dynamic "flip-flop" process in solution and reversible conformational isomerism of the chelated five-member...

We applied dynamic combinatorial chemistry (DCC) to identify ligands of ThiT, the S-component of the energy-coupling factor (ECF) transporter for thiamine in Lactococcus lactis. We used a pre-equilibrated dynamic combinatorial library (DCL) and saturation-transfer difference (STD) NMR spectroscopy to identify ligands of ThiT. This is the first report in which DCC is used for fragment growing to...

The NMR structure of the protein NP_247299.1 in solution at 313 K has been determined and is compared with the X-ray crystal structure, which was also solved in the Joint Center for Structural Genomics (JCSG) at 100 K and at 1.7 Å resolution. Both structures were obtained using the current largely automated crystallographic and solution NMR methods used by the JCSG. This paper assesses the accu...

Abstract. Photo-chemically induced dynamic nuclear polarization (photo-CIDNP) was used to observe the light-induced disproportionation reaction of 6,7,8-trimethyllumazine starting out from its triplet state generate a pair radicals comprising one-electron reduced and oxidized species. Our evidence is based on measurement two marker proton hyperfine couplings, Aiso(H(6α)) Aiso(H(8α)), which we c...